the human PTH1 receptor bound to an intracellular biased agonist
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8gw8
Q-score: 0.511
Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O
Nature (2023) 618 pp. 1085-1093 [ DOI: doi:10.1038/s41586-023-06169-3 Pubmed: 37286611 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Nanobody nb35 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- The human pth1 receptor bound to an intracellular biased agonist (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Pco-371 (635 Da, Ligand)
- Nanobody-35 (13 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex from Homo sapiens)
PTHrP-bound human PTH1R in complex with Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vvj
Q-score: 0.518
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Pthrp (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Nanobody nb35 (Complex)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
- Pthrp[1-36] (4 kDa, Protein from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class1)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vvk
Q-score: 0.444
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class2)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vvl
Q-score: 0.54
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
- Water (18 Da, Ligand)
PTH-bound human PTH1R in complex with Gs (class3)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vvm
Q-score: 0.454
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
PTH-bound human PTH1R in complex with Gs (class4)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7vvn
Q-score: 0.405
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex from Homo sapiens)
- Parathyroid hormone (Complex)
PTH-bound human PTH1R in complex with Gs (class5)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7vvo
Q-score: 0.359
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ Pubmed: 35932760 DOI: doi:10.1016/j.molcel.2022.07.003 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Pthrp (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Nanobody nb35 (Complex)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
Isoproterenol-activated dog beta3 adrenergic receptor
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xjh
Q-score: 0.494
Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O
Mol Cell (2021) 81 pp. 3205-3215.e5 [ DOI: doi:10.1016/j.molcel.2021.06.024 Pubmed: 34314699 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Nanobody nb35 (Complex from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Beta-3 adrenergic receptor (42 kDa, Protein from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Beta-3 adrenergic receptor (Complex from Canis lupus familiaris)
- Dog beta3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer (Complex)
- Isoprenaline (211 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7dh5
Q-score: 0.55
Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O
Mol Cell (2021) 81 pp. 3205-3215.e5 [ DOI: doi:10.1016/j.molcel.2021.06.024 Pubmed: 34314699 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Nanobody nb35 (Complex from unidentified)
- Beta-3 adrenergic receptor (42 kDa, Protein from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- 2-(2-azanyl-1,3-thiazol-4-yl)-n-[4-[2-[[(2r)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide (396 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Beta-3 adrenergic receptor (Complex from Canis lupus familiaris)
- Dog beta3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)