PTH-bound human PTH1R in complex with Gs (class2)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vvl
Q-score: 0.54
Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O
Mol Cell (2022) 82 pp. 3468-3483.e5 [ DOI: doi:10.1016/j.molcel.2022.07.003 Pubmed: 35932760 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from unidentified)
- Endogenous ligand-bound the human pth receptor in complex with gs (Complex from Homo sapiens)
- Nanobody nb35 (Complex)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (Complex)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Parathyroid hormone (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
Isoproterenol-activated dog beta3 adrenergic receptor
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xjh
Q-score: 0.494
Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O
Mol Cell (2021) 81 pp. 3205-3215.e5 [ Pubmed: 34314699 DOI: doi:10.1016/j.molcel.2021.06.024 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Nanobody-35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Beta-3 adrenergic receptor (42 kDa, Protein from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Dog beta3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer (Complex)
- Nanobody nb35 (Complex from unidentified)
- Beta-3 adrenergic receptor (Complex from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7dh5
Q-score: 0.55
Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O
Mol Cell (2021) 81 pp. 3205-3215.e5 [ Pubmed: 34314699 DOI: doi:10.1016/j.molcel.2021.06.024 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- 2-(2-azanyl-1,3-thiazol-4-yl)-n-[4-[2-[[(2r)-2-oxidanyl-2-phenyl-ethyl]amino]ethyl]phenyl]ethanamide (396 Da, Ligand)
- Beta-3 adrenergic receptor (42 kDa, Protein from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Dog beta3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer (Complex)
- Nanobody nb35 (Complex from unidentified)
- Beta-3 adrenergic receptor (Complex from Canis lupus familiaris)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)