Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8yn3
Q-score: 0.623
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (15 kDa, Protein from synthetic construct)
- Histamine-h2r-minigs-nb35 complex (Complex from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide,binding protein g(s) subunit alpha (29 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of alpha-synuclein gS87 fibril
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8jex
Q-score: 0.537
Hu J, Xia W, Zeng S, Lim YJ, Tao Y, Sun Y, Zhao L, Wang H, Le W, Li D, Zhang S, Liu C, Li YM
Nat Commun (2024) 15 pp. 2677-2677 [ DOI: doi:10.1038/s41467-024-46898-1 Pubmed: 38538591 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Cryo-em structure of alpha-synuclein gs87 fibril (Cellular component from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Unverified amino acid chain (783 Da, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8pok
Q-score: 0.501
Kock Z, Schnelle K, Persechino M, Umbach S, Schihada H, Januliene D, Parey K, Pockes S, Kolb P, Dotsch V, Moller A, Hilger D, Bernhard F
Nat Commun (2024) 15 pp. 1831-1831 [ Pubmed: 38418462 DOI: doi:10.1038/s41467-024-46096-z ]
- Histamine h2 receptor (41 kDa, Protein from Homo sapiens)
- Histamine h2 receptor (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- H2 receptor coupled to heterotrimeric gs protein (Complex)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 and guanine nucleotide-binding protein subunit gamma (fragment) (Complex from Homo sapiens)
Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iq6
Q-score: 0.517
Lv X, Gao K, Nie J, Zhang X, Zhang S, Ren Y, Sun X, Li Q, Huang J, Liu L, Zhang X, Zhang W, Liu X
Nat Commun (2023) 14 pp. 8136-8136 [ DOI: doi:10.1038/s41467-023-43922-8 Pubmed: 38065938 ]
- Cryo-em structure of latanoprost-bound prostaglandin-f2-alpha receptor-minigq-nb35 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nanobody 35 (14 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Prostaglandin f2-alpha receptor (42 kDa, Protein from Homo sapiens)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8ppu
Q-score: 0.532
Betancurt-Anzola L, Martinez-Carranza M, Delarue M, Zatopek KM, Gardner AF, Sauguet L
Nat Commun (2023) 14 pp. 8306-8306 [ DOI: doi:10.1038/s41467-023-44125-x Pubmed: 38097591 ]
- Magnesium ion (24 Da, Ligand)
- Dna polymerase ii small subunit (74 kDa, Protein from Pyrococcus abyssi GE5)
- Dna polymerase sliding clamp (29 kDa, Protein from Pyrococcus abyssi GE5)
- Binary complex of pold bound to pcna and a primer/template duplex containing three consecutive mismatches (Complex from Pyrococcus abyssi GE5)
- Dp2 (144 kDa, Protein from Pyrococcus abyssi GE5)
- Zinc ion (65 Da, Ligand)
- Dna (5'-d(p*ap*gp*cp*ap*cp*gp*gp*cp*tp*cp*gp*gp*cp*cp*cp*gp*g)-3') (7 kDa, DNA from Pyrococcus abyssi GE5)
- Dna (5'-d(p*cp*cp*gp*gp*gp*cp*cp*gp*ap*gp*cp*cp*gp*tp*(gs)p*(c7r)p*(pst)p*(pst)p*(pst))-3') (6 kDa, DNA from Pyrococcus abyssi GE5)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8ppv
Q-score: 0.547
Betancurt-Anzola L, Martinez-Carranza M, Delarue M, Zatopek KM, Gardner AF, Sauguet L
Nat Commun (2023) 14 pp. 8306-8306 [ DOI: doi:10.1038/s41467-023-44125-x Pubmed: 38097591 ]
- Magnesium ion (24 Da, Ligand)
- Dna polymerase ii small subunit (74 kDa, Protein from Pyrococcus abyssi GE5)
- Dna (5'-d(*p*cp*cp*gp*gp*gp*cp*cp*gp*ap*gp*cp*cp*gp*tp*(gs)p*(g7p)p*(pst)p*(pst)p*(pst))-3') (6 kDa, DNA from Pyrococcus abyssi GE5)
- Dna polymerase sliding clamp (29 kDa, Protein from Pyrococcus abyssi GE5)
- Binary complex of pold bound to pcna and a primer/template duplex containing three consecutive mismatches (Complex from Pyrococcus abyssi GE5)
- Dp2 (144 kDa, Protein from Pyrococcus abyssi GE5)
- Zinc ion (65 Da, Ligand)
- Dna (5'-d(p*ap*gp*cp*ap*cp*gp*gp*cp*tp*cp*gp*gp*cp*cp*cp*gp*g)-3') (7 kDa, DNA from Pyrococcus abyssi GE5)
Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8hti
Q-score: 0.583
Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ
Nat Commun (2023) 14 pp. 8105-8105 [ Pubmed: 38062020 DOI: doi:10.1038/s41467-023-43983-9 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Consensus olfactory receptor or52c (36 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Complex of consensus olfactory receptor or52c in complex with octanoic acid, g protein and nanobody 35 (nb35) (140 kDa, Complex from Homo sapiens)
- Octanoic acid (caprylic acid) (144 Da, Ligand)
Cryo-EM structure of the Methanosarcina mazei glutamine synthetase (GS) with Met-Sox-P and ADP
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8tfk
Q-score: 0.194
Schumacher MA, Salinas R, Travis BA, Singh RR, Lent N
Nat Commun (2023) 14 pp. 7375-7375 [ DOI: doi:10.1038/s41467-023-43243-w Pubmed: 37968329 ]
- M. mazei glutamine synthetase (gs) transition state complex (Complex from Methanosarcina mazei Go1)
- Magnesium ion (24 Da, Ligand)
- Glutamine synthetase (52 kDa, Protein from Methanosarcina mazei Go1)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- L-methionine-s-sulfoximine phosphate (260 Da, Ligand)
Cryo-EM structure of the GPR174-Gs complex bound to endogenous lysoPS
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8kh5
Q-score: 0.514
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ DOI: doi:10.1038/s41467-023-41654-3 Pubmed: 37737235 ]
- Cryo-em structure of the gpr174 and mini-gs complex with nb35 (Complex)
- Probable g-protein coupled receptor 174 (39 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- O-{hydroxy[((2r)-2-hydroxy-3-{[(1s)-1-hydroxypentadecyl]oxy}propyl)oxy]phosphoryl}-l-serine (485 Da, Ligand)
- Gs complex (Complex from Homo sapiens)
- Gpr174 (Complex from Homo sapiens)
Cryo-EM structure of the GPR161-Gs complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8kh4
Q-score: 0.48
Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S
Nat Commun (2023) 14 pp. 5901-5901 [ DOI: doi:10.1038/s41467-023-41654-3 Pubmed: 37737235 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr161 and mini-gs complex with nb35 (Complex from Homo sapiens)
- G-protein coupled receptor 161 (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(olf) subunit alpha,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)