Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc
Resolution: 2.39 Å
EM Method: Single-particle
Fitted PDBs: 9bws
Q-score: 0.554
To Be Published
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Decane (142 Da, Ligand)
- Hexane (86 Da, Ligand)
- Human k2p13.1 with s136p and y273a muatations in lipid nanodisc (Complex from Homo sapiens)
Structure of human K2P13.1 (THIK1) in detergent
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 9byi
Q-score: 0.515
To Be Published
- Hexadecane (226 Da, Ligand)
- Human k2p13.1 in detergent (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Hexane (86 Da, Ligand)
Structure of K2P13.1 (THIK1) S136P in detergent
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 9c07
Q-score: 0.57
Roy-Chowdhury S, Adberemane-Ali F, Minor DL
To Be Published
- Hexadecane (226 Da, Ligand)
- Homodimer of k2p13.1 (thik1) s136p mutant (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
Structure of K2P13.1 (THIK1) S136P in lipid nanodisc
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 9c09
Q-score: 0.576
To Be Published
- N-octane (114 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Homodimer of human k2p13.1 (thik1) with s136p activating mutation (80 kDa, Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Potassium channel subfamily k member 13 (39 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268
Resolution: 5.95 Å
EM Method: Single-particle
Fitted PDBs: 8wgc
Q-score: 0.215
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ Pubmed: 39609406 DOI: doi:10.1038/s41467-024-54744-7 ]
- Heterodimer of mglu2 and mglu4 bound with mglu2 agonist ly379268 (Complex from Homo sapiens)
- (1r,4r,5s,6r)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (187 Da, Ligand)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
CryoEM structure of human rho1 GABAA receptor in complex with estradiol
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8rh4
Q-score: 0.638
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with GABA and estradiol in primed state
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Estradiol (272 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)