CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Pregnenolone sulfate (396 Da, Ligand)
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Dodecane (170 Da, Ligand)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Decane (142 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with GABA and pregnenolone sulfate
Chen F, John C, Rebecca JH, Erik L
Nat Commun (2024) [ ]
- Pregnenolone sulfate (396 Da, Ligand)
- Hexane (86 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- N-octane (114 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human rho1 gabaa receptor in complex with estradiol (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vby
Q-score: 0.565
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E
Nature (2024) 632 pp. 672-677 [ Pubmed: 39112705 DOI: doi:10.1038/s41586-024-07739-9 ]
- Water (18 Da, Ligand)
- Pentane (72 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Heptane (100 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Pentadecane (212 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- N-octane (114 Da, Ligand)
- Decane (142 Da, Ligand)
- Methyl (1s,2r,3s,4r,5r)-4-{2-[(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)-9h-purin-9-yl}-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate (459 Da, Ligand)
- Methyl (1r,2s,3s,5s)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (277 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (63 kDa, Protein from Homo sapiens)
- Sodium dependent dopamine transporter in complex with inhibitor (63 kDa, Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8dn2
Q-score: 0.417
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- Nonane (128 Da, Ligand)
- Hexane (86 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Heptane (100 Da, Ligand)
- N-octane (114 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Undecane (156 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-butane (58 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state 2(expanded-open state) (240 kDa, Complex from Homo sapiens)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, apo state
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8dn3
Q-score: 0.482
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- Nonane (128 Da, Ligand)
- Hexane (86 Da, Ligand)
- Heteromeric glycine receptor alpha-1 and beta, apo state (240 kDa, Complex from Homo sapiens)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Heptane (100 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Undecane (156 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-butane (58 Da, Ligand)
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8dn5
Q-score: 0.462
Nat Commun (2023) 14 pp. 6377-6377 [ DOI: doi:10.1038/s41467-023-42051-6 Pubmed: 37821459 ]
- Nonane (128 Da, Ligand)
- Hexane (86 Da, Ligand)
- Glycine receptor subunit beta,green fluorescent protein,glycine receptor beta (76 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Heptane (100 Da, Ligand)
- N-octane (114 Da, Ligand)
- Heteromeric glycine receptor subunit alpha-1 and beta, glycine-bound state1 (open state) (240 kDa, Complex from Homo sapiens)
- Glycine receptor subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- Undecane (156 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-butane (58 Da, Ligand)
CryoEM structure of human rho1 GABAA receptor in complex with GABA
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8op9
Q-score: 0.484
Cowgill J, Fan C, Haloi N, Tobiasson V, Zhuang Y, Howard RJ, Lindahl E
Neuron (2023) 111 pp. 3450-3464.e5 [ DOI: doi:10.1016/j.neuron.2023.08.006 Pubmed: 37659407 ]
- Rho1 gabaa receptor (Complex from Homo sapiens)
- Hexane (86 Da, Ligand)
- Water (18 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit rho-1 (55 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8b01
Q-score: 0.539
Davies JS, Currie MJ, North RA, Scalise M, Wright JD, Copping JM, Remus DM, Gulati A, Morado DR, Jamieson SA, Newton-Vesty MC, Abeysekera GS, Ramaswamy S, Friemann R, Wakatsuki S, Allison JR, Indiveri C, Drew D, Mace PD, Dobson RCJ
Nat Commun (2023) 14 pp. 1120-1120 [ Pubmed: 36849793 DOI: doi:10.1038/s41467-023-36590-1 ]
- Hexane (86 Da, Ligand)
- Putative trap-type c4-dicarboxylate transport system, large permease component (45 kDa, Protein from Photobacterium profundum SS9)
- Megabody (Complex from Helicobacter pylori)
- Megabody c7hopq (54 kDa, Protein from synthetic construct)
- N-octane (114 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Siaqm (Complex from Photobacterium profundum)
- Decane (142 Da, Ligand)
- Tridecane (184 Da, Ligand)
- Putative trap-type c4-dicarboxylate transport system, small permease component (19 kDa, Protein from Photobacterium profundum SS9)
- Siaqm with megabody (Complex)
- Docosane (310 Da, Ligand)
Cryo-EM structure of LY2794193-bound mGlu3
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 7wih
Q-score: 0.421
Fang W, Yang F, Xu C, Ling S, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P, Pin JP, Tian C, Liu J
Cell Res (2022) 32 pp. 695-698 [ Pubmed: 35236939 DOI: doi:10.1038/s41422-022-00623-z ]
- (1s,2s,4s,5r,6s)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (334 Da, Ligand)
- Cryo-em structure of mglu3 bound with ly2794193 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 3 (100 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor bound by a-Cobratoxin
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7pc0
Q-score: 0.489
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS
Nature (2022) 602 pp. 529-533 [ Pubmed: 35140402 DOI: doi:10.1038/s41586-022-04402-z ]
- Gaba-a receptor pentamer bound by cobratoxin (240 kDa, Complex)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gaba-a receptor pentamer (Complex from Homo sapiens)
- Megabody 25 (56 kDa, Protein from Lama glama)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Alpha-cobratoxin (7 kDa, Protein from Naja kaouthia)
- Histamine (111 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (47 kDa, Protein from Homo sapiens)
- Cobratoxin (Complex from Naja kaouthia)
- Megabody 25 (Complex from Lama glama)