Negative stain EM map of an MTA-HDAC-MBD complex
Low JKK, Silva APG, Sharifi Tabar M, Torrado M, Webb SR, Parker BL, Sana M, Smits C, Schmidberger JW, Brillault L, Jackman MJ, Williams Jr DC, Blobel GA, Hake SB, Shepherd NE, Landsberg MJ, Mackay JP
Cell Rep (2020) 33 pp. 108450-108450 [ DOI: doi:10.1016/j.celrep.2020.108450 Pubmed: 33264611 ]
- Metastasis-associated protein mta2 (Protein from Mus musculus)
- Histone deacetylase 1 (Complex)
- Methyl-cpg-binding protein mbd3/gata zinc finger domain-containing protein 2a fusion (Protein from Mus musculus)
- Metastasis-associated protein mta2, (Complex from Homo sapiens)
- Mhm complex (300 kDa, Complex from Mus musculus)
- Histone deacetylase 1 (Protein from Homo sapiens)
SAGA-TBP filtered to show the position of the DUB domain
Resolution: 20.0 Å
EM Method: Single-particle
Fitted PDBs: 6tbm
Q-score: 0.08
Papai G, Frechard A, Kolesnikova O, Crucifix C, Schultz P, Ben-Shem A
Nature (2020) 577 pp. 711-716 [ DOI: doi:10.1038/s41586-020-1944-2 Pubmed: 31969704 ]
- Tata-box binding protein (tbp) (Complex from Komagataella phaffii GS115)
- Polyubiquitin-b (8 kDa, Protein from Homo sapiens)
- Tata-box binding protein (tbp) (27 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Transcription and mrna export factor sus1 (11 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Transcription initiation factor tfiid subunit 10 (23 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Saga component (Complex from Komagataella phaffii GS115)
- Saga complex (Complex from Komagataella phaffii GS115)
- Transcriptional regulator involved in glucose repression of gal4p-regulated genes (81 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Ubiquitin carboxyl-terminal hydrolase (56 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit of the saga and saga-like transcriptional regulatory complexes, interacts with spt15p to act (39 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit of the saga transcriptional regulatory complex, involved in proper assembly of the complex (136 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Spt8 (34 kDa, Protein from Komagataella phaffii GS115)
- Spt20 (59 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit (60 kda) of tfiid and saga complexes (54 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit (90 kda) of tfiid and saga complexes (80 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Transcriptional coactivator hfi1/ada1 (49 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit (61/68 kda) of tfiid and saga complexes (66 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Polyubiquitin-b (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Saga bound to tbp (1 MDa, Complex)
- Saga-associated factor 11 (13 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit of saga histone acetyltransferase complex (79 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Transcription-associated protein (438 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))
- Subunit (17 kda) of tfiid and saga complexes, involved in rna polymerase ii transcription initiation (17 kDa, Protein from Komagataella phaffii (strain GS115 / ATCC 20864))