CENP-A/H4 di-tetrasome assembled on alpha-satellite DNA.
Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapic S, Halic M, Cascella M, Sekulic N
bioRxiv (2025) [ DOI: doi:10.1101/2024.12.31.630874 Pubmed: 39803555 ]
- 2x(cenp-a/h4)2 di-tetrasome assembled on alpha-satellite dna. (200 MDa, Complex from Homo sapiens)
- 147 bp human alpha-satellite dna (45 kDa, DNA from Homo sapiens)
- Histone h3-like centromeric protein a (15 kDa, Protein from Homo sapiens)
- 147 bp alpha-satellite dna (45 kDa, DNA from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
H3/H4 di-tetrasome assembled on alpha-satellite DNA (closed conformation).
Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapic S, Halic M, Cascella M, Sekulic N
bioRxiv (2025) [ DOI: doi:10.1101/2024.12.31.630874 Pubmed: 39803555 ]
H3/H4 di-tetrasome assembled on alpha-satellite DNA (open conformation).
Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapic S, Halic M, Cascella M, Sekulic N
bioRxiv (2025) [ DOI: doi:10.1101/2024.12.31.630874 Pubmed: 39803555 ]
CENP-A/H4 tetra-tetrasome assembled on 342 bp alpha-satellite DNA.
Ali-Ahmad A, Mors M, Carrer M, Li X, Bilokapic S, Halic M, Cascella M, Sekulic N
bioRxiv (2025) [ DOI: doi:10.1101/2024.12.31.630874 Pubmed: 39803555 ]
Haspin bound to nucleosome in position 1
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9b2s
Q-score: 0.536
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- 601 dna (185-mer) (57 kDa, DNA from synthetic construct)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Haspin bound to nucleosome (Complex from Xenopus laevis)
- 601 dna (185-mer) (56 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
Haspin bound to nucleosome in position 2
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9b2t
Q-score: 0.502
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- 601 dna (185-mer) (57 kDa, DNA from synthetic construct)
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Haspin bound to nucleosome (Complex from Xenopus laevis)
- 601 dna (185-mer) (56 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 9b2u
Q-score: 0.363
Hicks CW, Gliech CR, Zhang X, Rahman S, Vasquez S, Holland AJ, Wolberger C
To Be Published
- Haspin bound to h3 tail (Complex from Xenopus laevis)
- Serine/threonine-protein kinase haspin (40 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
Cryo-EM structure of nucleosome containing Widom603 DNA
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8rgm
Q-score: 0.352
Motorin NA, Afonin D, Armeev GA, Moiseenko A, Zhao L, Vasiliev V, Oleinikov P, Shaytan A, Shi X, Studitsky V, Sokolova O
To Be Published
- Human nucleosome containing widom 603 dna sequence (Complex from Homo sapiens)
- Widom 603 dna sequence (44 kDa, DNA from synthetic construct)
- Histone h2b type 1-j (13 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Widom 603 dna sequence (44 kDa, DNA from synthetic construct)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8voj
Q-score: 0.392
To Be Published
- Isoform 2 of kelch repeat and btb domain-containing protein 4 (59 kDa, Protein from Homo sapiens)
- Rest corepressor 1 (45 kDa, Protein from Homo sapiens)
- (1r,4r)-n~1~-[(7p)-2-benzyl-7-(2-methyl-2h-tetrazol-5-yl)-9h-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine (453 Da, Ligand)
- Lhc-k4 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Histone deacetylase 1 (55 kDa, Protein from Homo sapiens)
The structure of LSD1-CoREST-HDAC1 in complex with KBTBD4IPR310delinsTTYML
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vpq
Q-score: 0.491
To Be Published
- Zinc ion (65 Da, Ligand)
- Histone deacetylase 1 (55 kDa, Protein from Homo sapiens)
- Isoform 2 of kelch repeat and btb domain-containing protein 4 (60 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Rest corepressor 1 (53 kDa, Protein from Homo sapiens)
- Lhc-k4ttyml (Complex from Homo sapiens)