H3K4me3 nucleosome bound to PRC2_AJ1-450
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vmn
Q-score: 0.39
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- H3k4me3 nucleosome core particle bound to prc2_aj1-450 (Complex from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h2b (10 kDa, Protein from Xenopus laevis)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h2a (11 kDa, Protein from Xenopus laevis)
PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vnv
Q-score: 0.357
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Prc2_aj1-450 bound to h3k36me3 modified nucleosome with tail engaged (Complex from Homo sapiens)
- Isoform 2 of histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (31 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- H3k36me3-modified histone h3 (2 kDa, Protein from Homo sapiens)
H3K36me3-modified nucleosome bound to PRC2_AJ1-450 with histone H3 tail disengaged
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vo0
Q-score: 0.258
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- H3k36me3 modified nucleosome core particle (Complex from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h4 (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (9 kDa, Protein from Xenopus laevis)
- Histone h4 (8 kDa, Protein from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h2a (11 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (9 kDa, Protein from Xenopus laevis)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
PRC2_AJ119-450 bound to H3K4me3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vmi
Q-score: 0.48
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Zinc ion (65 Da, Ligand)
- Histone h3.1 (747 Da, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Histone h3.1t (1 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj119-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
H3K4me3 nucleosome bound to PRC2_AJ119-450
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vmj
Q-score: 0.402
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h2b (10 kDa, Protein from Xenopus laevis)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h2a (11 kDa, Protein from Xenopus laevis)
- H3k4me3 modified nucleosome bound to prc2_aj119-450 (Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vml
Q-score: 0.366
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h3 (2 kDa, Protein from Homo sapiens)
- Aepb2 (34 kDa, Protein from Homo sapiens)
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Suz12 (83 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Jarid2 (139 kDa, Protein from Homo sapiens)
PRC2_AJ1-450 bound to H3K36me3-modified nucleosome with histone H3 tail disengaged
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vnz
Q-score: 0.325
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k36me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
H3K36me3-modified nucleosome bound to PRC2_AJ1-450
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vob
Q-score: 0.375
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (11 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (10 kDa, Protein from Xenopus laevis)
- H3k36me3 nucleosome core particle bound to prc2_aj1-450 (Complex from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
P400 subcomplex of the native human TIP60 complex
Yang Z, Mameri A, Cattoglio C, Lachance C, Florez Ariza AJ, Luo J, Humbert J, Sudarshan D, Banerjea A, Galloy M, Fradet-Turcotte A, Lambert JP, Ranish JA, Cote J, Nogales E
Science (2024) 385 pp. eadl5816-eadl5816 [ Pubmed: 39088653 DOI: doi:10.1126/science.adl5816 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Histone h2a.z (13 kDa, Protein from Homo sapiens)
- Ruvb-like 2 (51 kDa, Protein from Homo sapiens)
- Dna methyltransferase 1-associated protein 1 (53 kDa, Protein from Homo sapiens)
- Actin-like protein 6a (47 kDa, Protein from Homo sapiens)
- Ruvb-like 1 (50 kDa, Protein from Homo sapiens)
- E1a-binding protein p400 (343 kDa, Protein from Homo sapiens)
- Enhancer of polycomb homolog 1 (93 kDa, Protein from Homo sapiens)
- Reconstituted p400 subcomplex of the human tip60 complex (Complex from Homo sapiens)
- Histone h2b type 1-b (13 kDa, Protein from Homo sapiens)
- Vacuolar protein sorting-associated protein 72 homolog (40 kDa, Protein from Homo sapiens)
- Actin, cytoplasmic 1 (41 kDa, Protein from Homo sapiens)
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ DOI: doi:10.1126/science.abc3393 Pubmed: 33479123 ]
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)