Cryo-EM structure of the inward-facing FLVCR1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qcs
Q-score: 0.554
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
- Flvcr1 monomer (60 kDa, Complex from Homo sapiens)
Cryo-EM structure of the inward-facing choline-bound FLVCR1
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8qct
Q-score: 0.631
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
- Choline-bound flvcr1 monomer (60 kDa, Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Cryo-EM structure of the inward-facing ethanolamine-bound FLVCR1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8r8t
Q-score: 0.581
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
- Ethanolamine (61 Da, Ligand)
- Ethanolamine-bound flvcr1 monomer (60 kDa, Complex from Homo sapiens)
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8ubw
Q-score: 0.577
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024) 629 pp. 710-716 [ Pubmed: 38693265 DOI: doi:10.1038/s41586-024-07374-4 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Heme transporter flvcr1 (59 kDa, Protein from Homo sapiens)
- Human flvcr1 (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8ubx
Q-score: 0.579
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024) 629 pp. 710-716 [ Pubmed: 38693265 DOI: doi:10.1038/s41586-024-07374-4 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Ethanolamine (61 Da, Ligand)
- Heme transporter flvcr1 (59 kDa, Protein from Homo sapiens)
- Human flvcr1 (Complex from Homo sapiens)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8uby
Q-score: 0.566
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024) 629 pp. 710-716 [ Pubmed: 38693265 DOI: doi:10.1038/s41586-024-07374-4 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Heme transporter flvcr1 (59 kDa, Protein from Homo sapiens)
- Human flvcr1 (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8ubz
Q-score: 0.49
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024) 629 pp. 710-716 [ Pubmed: 38693265 DOI: doi:10.1038/s41586-024-07374-4 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Heme transporter flvcr1 (59 kDa, Protein from Homo sapiens)
- Human flvcr1 (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Endogenous ligand bound FLVCR1
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 8uc0
Q-score: 0.618
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024) 629 pp. 710-716 [ Pubmed: 38693265 DOI: doi:10.1038/s41586-024-07374-4 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human flvcr1 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Heme transporter flvcr1 (59 kDa, Protein from Homo sapiens)