Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 9fno
Q-score: 0.203
Etzerodt A, Mikkelsen JH, Torvund-Jensen M, Hennig D, Boesen T, Graversen JH, Moestrup SK, Kollman JM, Andersen CBF
Nat Commun (2024) 15 pp. 10871-10871 [ Pubmed: 39738064 DOI: doi:10.1038/s41467-024-55171-4 ]
- Hemopressin (15 kDa, Protein from Homo sapiens)
- Cd163 in complex with haptoglobin-hemoglobin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Scavenger receptor cysteine-rich type 1 protein m130 (125 kDa, Protein from Homo sapiens)
- Spinorphin (16 kDa, Protein from Homo sapiens)
- Haptoglobin beta chain (27 kDa, Protein from Homo sapiens)
- Isoform 2 of haptoglobin alpha chain (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 9fhb
Q-score: 0.405
Etzerodt A, Mikkelsen JH, Torvund-Jensen M, Hennig D, Boesen T, Graversen JH, Moestrup SK, Kollman JM, Andersen CBF
Nat Commun (2024) 15 pp. 10871-10871 [ Pubmed: 39738064 DOI: doi:10.1038/s41467-024-55171-4 ]
- Hemoglobin subunit beta (16 kDa, Protein from Homo sapiens)
- Cd163 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Hemoglobin subunit alpha (15 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Scavenger receptor cysteine-rich type 1 protein m130 (125 kDa, Protein from Homo sapiens)
- Haptoglobin-hemoglobin complex (Complex from Homo sapiens)
- Haptoglobin (45 kDa, Protein from Homo sapiens)
- Cd163 in complex with haptoglobin-hemoglobin (Complex)
Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 9fmu
Q-score: 0.233
Etzerodt A, Mikkelsen JH, Torvund-Jensen M, Hennig D, Boesen T, Graversen JH, Moestrup SK, Kollman JM, Andersen CBF
Nat Commun (2024) 15 pp. 10871-10871 [ Pubmed: 39738064 DOI: doi:10.1038/s41467-024-55171-4 ]
- Hemopressin (15 kDa, Protein from Homo sapiens)
- Isoform 2 of haptoglobin (38 kDa, Protein from Homo sapiens)
- Cd163 in complex with haptoglobin-hemoglobin (Complex from Homo sapiens)
- Scavenger receptor cysteine-rich type 1 protein m130 (112 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Spinorphin (16 kDa, Protein from Homo sapiens)
cryo-EM structure of alligator haemoglobin in carbonmonoxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Carbon monoxide (28 Da, Ligand)
- Alligator haemoglobin in carbonmonoxy form (100 kDa, Complex from Alligator mississippiensis)
- Hemoglobin subunit beta (16 kDa, Protein from Alligator mississippiensis)
- Water (18 Da, Ligand)
- Hemoglobin subunit alpha (15 kDa, Protein from Alligator mississippiensis)
cryo-EM structure of alligator haemoglobin in oxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Alligator haemoglobin in carboxy form (100 kDa, Complex from Alligator mississippiensis)
- Hemoglobin subunit beta (16 kDa, Protein from Alligator mississippiensis)
- Water (18 Da, Ligand)
- Oxygen molecule (31 Da, Ligand)
- Hemoglobin subunit alpha (15 kDa, Protein from Alligator mississippiensis)
cryo-EM structure of alligator haemoglobin in deoxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Bicarbonate ion (61 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Alligator haemoglobin in carboxy form (100 kDa, Complex from Alligator mississippiensis)
- Hemoglobin subunit beta (16 kDa, Protein from Alligator mississippiensis)
- Water (18 Da, Ligand)
- Hemoglobin subunit alpha (15 kDa, Protein from Alligator mississippiensis)
cryo-EM structure of human haemoglobin in carbonmonoxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Hemoglobin subunit beta (16 kDa, Protein from Homo sapiens)
- Hemoglobin subunit alpha (15 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Carbon monoxide (28 Da, Ligand)
- Human haemoglobin in carbonmonoxy form (100 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
cryo-EM structure of human haemoglobin in oxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Human haemoglobin in oxy form (100 kDa, Complex from Homo sapiens)
- Oxygen molecule (31 Da, Ligand)
- Hemoglobin subunit beta (16 kDa, Protein from Homo sapiens)
- Hemoglobin subunit alpha (15 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Water (18 Da, Ligand)
cryo-EM structure of human haemoglobin in deoxy form
Takahashi K, Lee Y, Fago A, Bautista NM, Storz JF, Kawamoto A, Kurisu G, Nishizawa T, Tame JRH
Nat Commun (2024) 15 pp. 6505-6505 [ Pubmed: 39090102 DOI: doi:10.1038/s41467-024-49947-x ]
- Human haemoglobin in deoxy form (100 kDa, Complex from Homo sapiens)
- Hemoglobin subunit beta (16 kDa, Protein from Homo sapiens)
- Hemoglobin subunit alpha (15 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8the
Q-score: 0.664
Knejski PP, Erramilli SK, Kossiakoff AA
Structure (2024) 32 pp. 411- [ Pubmed: 38325368 DOI: doi:10.1016/j.str.2024.01.007 ]
- Synthetic antibody heavy chain (25 kDa, Protein from Homo sapiens)
- Heme bound p. aeruginosa phur with bound synthetic antibody (Complex from Pseudomonas aeruginosa)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Synthetic antibody light chain (23 kDa, Protein from Homo sapiens)
- (2~{r},4~{r},5~{s},6~{s})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[[(2~{r},3~{s},4~{s},5~{r},6~{s})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{r},4~{r},5~{s},6~{s})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{s})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- Heme/hemoglobin uptake outer membrane receptor phur (86 kDa, Protein from Pseudomonas aeruginosa)
- Water (18 Da, Ligand)