PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vnv
Q-score: 0.357
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Prc2_aj1-450 bound to h3k36me3 modified nucleosome with tail engaged (Complex from Homo sapiens)
- Isoform 2 of histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (31 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- H3k36me3-modified histone h3 (2 kDa, Protein from Homo sapiens)
PRC2_AJ119-450 bound to H3K4me3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vmi
Q-score: 0.48
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Zinc ion (65 Da, Ligand)
- Histone h3.1 (747 Da, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Histone h3.1t (1 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj119-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
Automethylated PRC2 dimer bound to nucleosome
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 8t9g
Q-score: 0.163
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Proximal prc2 (Complex from Homo sapiens)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Distal prc2 (Complex from Homo sapiens)
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Activating methylated peptide (1 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Automethylated prc2 dimer bound to nucleosome (290 kDa, Complex from Homo sapiens)
- Nucleosome (Complex from Xenopus laevis)
PRC2 monomer bound to nucleosome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8tas
Q-score: 0.259
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Nucleosome (Complex from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Prc2 monomer bound to nucleosome (290 kDa, Complex from Homo sapiens)
- Prc2 (Complex from Homo sapiens)
PRC2-J119-450 monomer bound to H1-nucleosome
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tb9
Q-score: 0.261
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Protein jumonji (36 kDa, Protein from Homo sapiens)
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Histone h1.0 (21 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Prc2-j119-450 monomer bound to h1-nucleosome (290 kDa, Complex from Homo sapiens)
- Prc2 (Complex from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Nucleosome (Complex from Xenopus laevis)
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ DOI: doi:10.1126/science.abc3393 Pubmed: 33479123 ]
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Resolution: 20.0 Å
EM Method: Single-particle
Fitted PDBs: 6v92
Q-score: 0.053
Patel AB, Moore CM, Greber BJ, Luo J, Zukin SA, Ranish J, Nogales E
eLife (2019) 8 [ Pubmed: 31886770 DOI: doi:10.7554/eLife.54449 ]
- Chromatin structure-remodeling complex subunit rsc2 (102 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Unknown protein (1 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc14 (19 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc8 (63 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Unknown protein (1 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Uuknown protein (1 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex subunit rsc7 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Chromatin structure-remodeling complex subunit rsc9 (65 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone h2b type 1-k (13 kDa, Protein from Homo sapiens)
- Chromatin structure-remodeling complex subunit rsc4 (72 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Nuclear protein sth1/nps1 (156 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- High temperature lethal protein 1 (9 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Rsc-ncp complex (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc3 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc58 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex subunit sfh1 (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Unknown protein (2 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc6 (54 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Actin-related protein 7 (53 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Actin-like protein arp9 (53 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Chromatin structure-remodeling complex protein rsc30 (101 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Unknown protein (4 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Regulator of ty1 transposition protein 102 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))