Structure of a human EMC:human Cav1.2 channel complex in GDN detergent (ECAB Map 3)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8eoi
Q-score: 0.411
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
- Er membrane protein complex subunit 1 (109 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
- Er membrane protein complex subunit 10 (17 kDa, Protein from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1c (176 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 4 (18 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Er membrane protein complex subunit 7 (13 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (36 kDa, Protein from Oryctolagus cuniculus)
Human EMC:human Cav1.2 channel complex (Segment map 01)
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
Human EMC:human Cav1.2 channel complex in GDN detergent (Segment map 02)
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
Human EMC:human Cav1.2 channel complex in GDN detergent (ECAB Map 1, Consensus Map)
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
Human EMC:human Cav1.2 channel complex in GDN detergent (ECAB Map 2, Consensus Map)
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
Human ER membrane protein complex (EMC) in GDN, 9-subunit map
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8s9s
Q-score: 0.404
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Human er membrane protein complex (Complex from Homo sapiens)
- Membrane magnesium transporter 1 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
Human ER membrane protein complex (EMC) in GDN, Consensus map
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Er membrane protein complex subunit 6 (Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (Protein from Homo sapiens)
- Human er membrane protein complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 7 (Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (Protein from Homo sapiens)
Human ER membrane protein complex (EMC) in GDN, 8-subunit map
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Human er membrane protein complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 4 (Protein)
- Er membrane protein complex subunit 2 (Protein)
- Er membrane protein complex subunit 3 (Protein)
- Er membrane protein complex subunit 5 (Protein)
- Er membrane protein complex subunit 1 (Protein)
- Er membrane protein complex subunit 8 (Protein)
- Er membrane protein complex subunit 7 (Protein)
- Er membrane protein complex subunit 6 (Protein)
human EMC:human Cav1.2 channel complex in GDN detergent at 3.1 Angstrom
Nat Struct Mol Biol (2023) 30 pp. 735-739 [ Pubmed: 36973510 DOI: doi:10.1038/s41594-023-00951-7 ]
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
Human ER Membrane protein Complex (EMC)
O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS
eLife (2020) 9 [ Pubmed: 32459176 DOI: doi:10.7554/eLife.57887 ]
- Human er membrane protein complex (emc) (330 kDa, Complex from Homo sapiens)