Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3u
Q-score: 0.462
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil (Complex)
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 6d6t
Q-score: 0.46
Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE
Nature (2018) 559 pp. 67-72 [ Pubmed: 29950725 DOI: doi:10.1038/s41586-018-0255-3 ]
- Gamma-aminobutyric acid receptor subunit beta-2,gamma-aminobutyric acid receptor subunit beta-2 (39 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil, conformation b (348 kDa, Complex from Homo sapiens)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor subunit gamma-2 (40 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.92 Å
EM Method: Single-particle
Fitted PDBs: 6d6u
Q-score: 0.461
Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE
Nature (2018) 559 pp. 67-72 [ Pubmed: 29950725 DOI: doi:10.1038/s41586-018-0255-3 ]
- Gamma-aminobutyric acid receptor subunit gamma-2,gamma-aminobutyric acid receptor subunit gamma-2 (45 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2,gamma-aminobutyric acid receptor subunit beta-2 (39 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil, conformation a (348 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)