The Vo region of human V-ATPase in state 1 (focused refinement)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6wlw
Q-score: 0.579
Wang L, Wu D, Robinson CV, Wu H, Fu TM
Mol Cell (2020) 80 pp. 501- [ DOI: doi:10.1016/j.molcel.2020.09.029 Pubmed: 33065002 ]
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Renin receptor (39 kDa, Protein from Homo sapiens)
- Tri(methyl)-[2-[[(2~{r})-2-[(~{z})-octadec-9-enoyl]oxy-3-[(~{e})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium (787 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- 1,2-dicaproyl-sn-phosphatidyl-l-serine (455 Da, Ligand)
- Methyl (3r,6z,10e,14e)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate (534 Da, Ligand)
- Human v-atpase with sidk (Complex from Homo sapiens)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Homo sapiens)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Human V-ATPase in state 2 with SidK and ADP
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6wm3
Q-score: 0.477
Wang L, Wu D, Robinson CV, Wu H, Fu TM
Mol Cell (2020) 80 pp. 501- [ DOI: doi:10.1016/j.molcel.2020.09.029 Pubmed: 33065002 ]
- Renin receptor (39 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d (28 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit g 1 (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
- Human v-atpase with sidk and adp (Complex from Homo sapiens)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit h (55 kDa, Protein from Homo sapiens)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Homo sapiens)
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Homo sapiens)
- Sidk (65 kDa, Protein from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513))
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit f (13 kDa, Protein from Homo sapiens)
Human V-ATPase in state 3 with SidK and ADP
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6wm4
Q-score: 0.442
Wang L, Wu D, Robinson CV, Wu H, Fu TM
Mol Cell (2020) 80 pp. 501- [ DOI: doi:10.1016/j.molcel.2020.09.029 Pubmed: 33065002 ]
- Renin receptor (39 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d (28 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit g 1 (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
- Human v-atpase with sidk and adp (Complex from Homo sapiens)
- Sidk (65 kDa, Protein from Legionella pneumophila)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit h (55 kDa, Protein from Homo sapiens)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Homo sapiens)
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit f (13 kDa, Protein from Homo sapiens)