Structure of human ENPP1 in complex with variable heavy domain VH27.2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ghr
Q-score: 0.546
Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA
Nat Chem Biol (2024) 20 pp. 30-41 [ Pubmed: 37400538 DOI: doi:10.1038/s41589-023-01368-5 ]
- Water (18 Da, Ligand)
- Adenosine monophosphate (347 Da, Ligand)
- Vh27 (13 kDa, Protein from Homo sapiens)
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, immunoglobulin gamma-1 heavy chain fusion (115 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Enpp1-vh27 complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8a64
Q-score: 0.271
Trastoy B, Du JJ, Cifuente JO, Rudolph L, Garcia-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME
Nat Commun (2023) 14 pp. 1705-1705 [ DOI: doi:10.1038/s41467-023-37215-3 Pubmed: 36973249 ]
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7x13
Q-score: 0.273
To Be Published
- Igg-fc hexamer (300 kDa, Complex from Homo sapiens)
- Immunoglobulin gamma-1 heavy chain (27 kDa, Protein from Homo sapiens)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dv1
Q-score: 0.415
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd432 (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion,immunoglobulin gamma-1 heavy chain (110 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dv2
Q-score: 0.394
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Spike glycoprotein (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (113 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd293 (Complex from Severe acute respiratory syndrome coronavirus 2)
cryo EM map of the S protein of SARS-CoV-2 in complex bound with P2B-1A10
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7czq
Q-score: 0.385
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ig c642_heavy_ighv3-53_ighd1-26_ighj6,chain h of p2b-1a10,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p2b-1a10 (Complex from Homo sapiens)
- Immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-2G9
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7czt
Q-score: 0.44
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S protein of sars-cov-2 in complex bound with p2b-2g9 (Complex from Homo sapiens)
- Immunoglobulin heavy variable 3-33,chainh of p5a-2g9,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- Ig c689_light_iglv5-37_iglj3,igl@ protein (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B6_2B
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7czu
Q-score: 0.324
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Immunoglobulin heavy variable 3-30-3,immunoglobulin heavy variable 3-30-3,chain h of p5a-1b6_2b,immunoglobulin gamma-1 heavy chain,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- Immunoglobulin kappa variable 1-33,immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 in complex bound with p5a-1b6_2b (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7czv
Q-score: 0.26
Yan R, Wang R, Ju B, Yu J, Zhang Y, Liu N, Wang J, Zhang Q, Chen P, Zhou B, Li Y, Shen Y, Zhang S, Tian L, Guo Y, Xia L, Zhong X, Cheng L, Ge X, Zhao J, Wang HW, Wang X, Zhang Z, Zhang L, Zhou Q
Cell Res (2021) 31 pp. 517-525 [ DOI: doi:10.1038/s41422-021-00487-9 Pubmed: 33731853 ]
- Immunoglobulin heavy variable 3-30-3,chain h of p5a-1b6_3b,immunoglobulin gamma-1 heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S protein of sars-cov-2 in complex bound with p5a-1b6_3b (Complex from Homo sapiens)
- Immunoglobulin kappa variable 1-33,uncharacterized protein (23 kDa, Protein from Homo sapiens)
Cryo-EM reconstruction of C1-IgG1 complex
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 6fcz
Q-score: 0.013
Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P
Science (2018) 359 pp. 794-797 [ DOI: doi:10.1126/science.aao4988 Pubmed: 29449492 ]
- Complement c1q subcomponent subunit c (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Complement c1q (Complex from Homo sapiens)
- C1-igg1 complex (Complex)
- Complement c1q subcomponent subunit b (14 kDa, Protein from Homo sapiens)
- Immunoglobulin gamma-1 heavy chain (24 kDa, Protein from Homo sapiens)
- Immunoglobulin gamma-1 (Complex from Homo sapiens)
- Complement c1q subcomponent subunit a (14 kDa, Protein from Homo sapiens)