Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8u4c
Q-score: 0.359
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Long form insulin receptor (ir-b) with four igf2 bound, symmetric conformation. (Complex from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
- Insulin receptor (156 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8u4e
Q-score: 0.279
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Long form insulin receptor (ir-b) with three igf2 bound, asymmetric conformation. (Complex from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
CryoEM structure of MFRV-VILP bound to IGF1Rzip
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8tan
Q-score: 0.424
Chrudinova M, Kirk NS, Chuard A, Venugopal H, Zhang F, Lubos M, Gelfanov V, Panikova T, Zakova L, Cutone J, Mojares M, DiMarchi R, Jiracek J, Altindis E
Mol Metab (2024) 80 pp. 101863-101863 [ Pubmed: 38182007 DOI: doi:10.1016/j.molmet.2023.101863 ]
- Insulin-like growth factor (6 kDa, Protein from Mandarin fish ranavirus)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Mfrv-vilp (Complex from Mandarin fish ranavirus)
- 1:2 complex of mfrv-vilp bound to igf1rzip (Complex)
- Igf1rzip (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u23
Q-score: 0.188
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinova M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
Nat Commun (2022) 13 pp. 6700-6700 [ DOI: doi:10.1038/s41467-022-34391-6 Pubmed: 36335114 ]
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8eyr
Q-score: 0.346
Li J, Wu J, Hall C, Bai XC, Choi E
eLife (2022) 11 [ Pubmed: 36413010 DOI: doi:10.7554/eLife.81286 ]
- Two igf1 bound full-length mouse igf1r mutant (four glycine residues inserted in the alpha-ct; igf1r-p674g4): symmetric conformation (Complex from Mus musculus)
- Insulin-like growth factor 1 receptor (144 kDa, Protein from Mus musculus)
- Insulin-like growth factor i (21 kDa, Protein from Homo sapiens)
Structure of M-6-P/IGFII Receptor and IGFII complex
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 6um2
Q-score: 0.356
Wang R, Qi X, Schmiege P, Coutavas E, Li X
Sci Adv (2020) 6 pp. eaaz1466- [ DOI: doi:10.1126/sciadv.aaz1466 ]
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Cation-independent mannose-6-phosphate receptor (274 kDa, Protein from Bos taurus)
- Igfiir and igfii complex (Complex)
- Cation-independent mannose-6-phosphate receptor (Complex from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (Complex from Homo sapiens)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6pyh
Q-score: 0.392
Nat Commun (2019) 10 pp. 4567-4567 [ DOI: doi:10.1038/s41467-019-12564-0 Pubmed: 31594955 ]
- Full-length mmigf1r-hsigf1 complex (336 kDa, Complex)
- Insulin-like growth factor 1 receptor (145 kDa, Protein from Mus musculus)
- Hsigf1 (Complex from Homo sapiens)
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- Mmigf1r (Complex from Mus musculus)