Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ouf
Q-score: 0.431
Barski MS, Vanzo T, Zhao XZ, Smith SJ, Ballandras-Colas A, Cronin NB, Pye VE, Hughes SH, Burke Jr TR, Cherepanov P, Maertens GN
Nat Commun (2021) 12 pp. 4996-4996 [ DOI: doi:10.1038/s41467-021-25284-1 Pubmed: 34404793 ]
- Dna (5'-d(*ap*cp*tp*gp*tp*gp*tp*tp*tp*gp*gp*cp*gp*cp*tp*tp*cp*tp*cp*tp*c)-3') (9 kDa, DNA from Simian T-lymphotropic virus 1)
- Integrase (33 kDa, Protein from Simian T-lymphotropic virus 1)
- Zinc ion (65 Da, Ligand)
- Complex of stlv-1 marb43 integrase with nascent viral dna, the human pp2a b56 subunit and the drug inhibitor xz450 (331 kDa, Complex)
- Magnesium ion (24 Da, Ligand)
- 4-azanyl-~{n}-[[2,4-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)-3-oxidanylidene-propyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide (445 Da, Ligand)
- Water (18 Da, Ligand)
- Isoform 3 of pc4 and sfrs1-interacting protein,isoform gamma-1 of serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (80 kDa, Protein from Homo sapiens)
- Dna (5'-d(*gp*ap*gp*ap*gp*ap*ap*gp*cp*gp*cp*cp*ap*ap*ap*cp*ap*cp*a)-3') (8 kDa, DNA from Simian T-lymphotropic virus 1)
STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7oug
Q-score: 0.419
Barski MS, Vanzo T, Zhao XZ, Smith SJ, Ballandras-Colas A, Cronin NB, Pye VE, Hughes SH, Burke Jr TR, Cherepanov P, Maertens GN
Nat Commun (2021) 12 pp. 4996-4996 [ DOI: doi:10.1038/s41467-021-25284-1 Pubmed: 34404793 ]
- Dna (5'-d(*ap*cp*tp*gp*tp*gp*tp*tp*tp*gp*gp*cp*gp*cp*tp*tp*cp*tp*cp*tp*c)-3') (9 kDa, DNA from Simian T-lymphotropic virus 1)
- Complex of stlv-1 marb43 integrase with nascent viral dna, the human pp2a b56 subunit and the inhibitor raltegravir (331 kDa, Complex)
- Integrase (33 kDa, Protein from Simian T-lymphotropic virus 1)
- Zinc ion (65 Da, Ligand)
- N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide (444 Da, Ligand)
- Isoform 3 of pc4 and sfrs1-interacting protein,isoform gamma-2 of serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Dna (5'-d(*gp*ap*gp*ap*gp*ap*ap*gp*cp*gp*cp*cp*ap*ap*ap*cp*ap*cp*a)-3') (8 kDa, DNA from Simian T-lymphotropic virus 1)
Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ouh
Q-score: 0.354
Barski MS, Vanzo T, Zhao XZ, Smith SJ, Ballandras-Colas A, Cronin NB, Pye VE, Hughes SH, Burke Jr TR, Cherepanov P, Maertens GN
Nat Commun (2021) 12 pp. 4996-4996 [ DOI: doi:10.1038/s41467-021-25284-1 Pubmed: 34404793 ]
- Dna (5'-d(*ap*cp*tp*gp*tp*gp*tp*tp*tp*gp*gp*cp*gp*cp*tp*tp*cp*tp*cp*tp*c)-3') (9 kDa, DNA from Simian T-lymphotropic virus 1)
- Integrase (33 kDa, Protein from Simian T-lymphotropic virus 1)
- Complex of stlv-1 marb43 integrase with nascent viral dna, the human pp2a b56 subunit and the drug inhibitor bictegravir (331 kDa, Complex)
- Integrase (Complex from Simian T-lymphotropic virus 1)
- Zinc ion (65 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Pc4 and sfrs1-interacting protein,serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (80 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna (Complex from Simian T-lymphotropic virus 1)
- Pc4 and sfrs1-interacting protein,serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Dna (5'-d(*gp*ap*gp*ap*gp*ap*ap*gp*cp*gp*cp*cp*ap*ap*ap*cp*ap*cp*a)-3') (8 kDa, DNA from Simian T-lymphotropic virus 1)