The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8xrp
Q-score: 0.335
Chen H, Ge X, Li C, Zeng J, Wang X
Structure (2024) 32 pp. 1640- [ DOI: doi:10.1016/j.str.2024.07.010 Pubmed: 39111304 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The cryo-em structure of il-12, receptor subunit beta-1 and receptor subunit beta-2 complex (485 kDa, Complex from Homo sapiens)
- Interleukin-12 subunit alpha (23 kDa, Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-2 (34 kDa, Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Interleukin-12 subunit beta (34 kDa, Protein from Homo sapiens)
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8yi7
Q-score: 0.434
Chen H, Ge X, Li C, Zeng J, Wang X
Structure (2024) 32 pp. 1640- [ DOI: doi:10.1016/j.str.2024.07.010 Pubmed: 39111304 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The ternary complex of il-12 with il-12r beta-1 and il-12r beta-2 (120 kDa, Complex from Homo sapiens)
- Interleukin-12 subunit alpha (23 kDa, Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-2 (34 kDa, Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Interleukin-12 subunit beta (34 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8odz
Q-score: 0.329
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8oe0
Q-score: 0.208
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8pb1
Q-score: 0.424
Bloch Y, Felix J, Merceron R, Provost M, Symakani RA, De Backer R, Lambert E, Mehdipour AR, Savvides SN
Nat Struct Mol Biol (2024) 31 pp. 591-597 [ Pubmed: 38287195 DOI: doi:10.1038/s41594-023-01190-6 ]
- Murine il-12 in complex with mil-12rbeta1-dapk1 and mil-12rbeta2-calmodulin. (216 kDa, Complex from Mus musculus)
- Interleukin-12 receptor subunit beta-1,death-associated protein kinase 1 (63 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-12 subunit alpha (25 kDa, Protein from Mus musculus)
- Interleukin-12 subunit beta (35 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Interleukin-12 receptor subunit beta-2,calmodulin-1 (85 kDa, Protein from Mus musculus)
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC
Cell (2021) 184 pp. 983-999.e24 [ DOI: doi:10.1016/j.cell.2021.01.018 Pubmed: 33606986 ]
- Interleukin-12 subunit alpha (Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-2 (Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-1 (Protein from Homo sapiens)
- Il-12 receptor extracellular domain complex (153 MDa, Complex from Homo sapiens)
- Interleukin-12 subunit beta (Protein from Homo sapiens)