Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j7m
Q-score: 0.53
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Cholesterol (386 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment) (90 kDa, Protein from Aequorea victoria)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j7h
Q-score: 0.448
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Ion channel (91 kDa, Protein from Homo sapiens)
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8hkf
Q-score: 0.546
Zhang J, Liu S, Fan J, Yan R, Huang B, Zhou F, Yuan T, Gong J, Huang Z, Jiang D
Cell Rep (2023) 42 pp. 112858-112858 [ Pubmed: 37494189 DOI: doi:10.1016/j.celrep.2023.112858 ]
- Potassium channel subfamily t member 1 (139 kDa, Protein from Homo sapiens)
- Ion channel (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8hkk
Q-score: 0.509
Zhang J, Liu S, Fan J, Yan R, Huang B, Zhou F, Yuan T, Gong J, Huang Z, Jiang D
Cell Rep (2023) 42 pp. 112858-112858 [ Pubmed: 37494189 DOI: doi:10.1016/j.celrep.2023.112858 ]
- Potassium channel subfamily t member 1 (139 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8hkm
Q-score: 0.512
Zhang J, Liu S, Fan J, Yan R, Huang B, Zhou F, Yuan T, Gong J, Huang Z, Jiang D
Cell Rep (2023) 42 pp. 112858-112858 [ Pubmed: 37494189 DOI: doi:10.1016/j.celrep.2023.112858 ]
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Potassium channel subfamily t member 1 (139 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hkq
Q-score: 0.334
Zhang J, Liu S, Fan J, Yan R, Huang B, Zhou F, Yuan T, Gong J, Huang Z, Jiang D
Cell Rep (2023) 42 pp. 112858-112858 [ Pubmed: 37494189 DOI: doi:10.1016/j.celrep.2023.112858 ]
- Potassium channel subfamily t member 1 (139 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
- ~{n}-[(1~{s})-1-[3-(2-methoxypyridin-4-yl)-1,2,4-oxadiazol-5-yl]ethyl]-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide (396 Da, Ligand)
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 7cfs
Q-score: 0.483
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
eLife (2020) 9 [ Pubmed: 32915133 DOI: doi:10.7554/eLife.57096 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Acid-sensing ion channel 1 (54 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hasic1a (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7cft
Q-score: 0.436
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
eLife (2020) 9 [ Pubmed: 32915133 DOI: doi:10.7554/eLife.57096 ]
- Mambalgin-1 (6 kDa, Protein from Dendroaspis polylepis polylepis)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hasic1a-mamba1 (Complex from Homo sapiens)
- Acid-sensing ion channel 1 (54 kDa, Protein from Homo sapiens)
Map of an acid-sensing ion channel in a desensitized state after photo-uncaging protons.
Yoder N, Jalali-Yazdi F, Noreng S, Houser A, Baconguis I, Gouaux E
J Struct Biol (2020) 212 pp. 107624-107624 [ DOI: doi:10.1016/j.jsb.2020.107624 Pubmed: 32950604 ]
- Acid-sensing ion channel (180 kDa, Complex from Gallus gallus)
- Acid-sensing ion channel (Protein from Gallus gallus)