Cryo-EM structure of Arabidopsis CNGC1
Wang J, Du BY, Zhang X, Qu X, Yang Y, Yang Z, Wang YF, Zhang P
Nat Plants (2025) [ Pubmed: 39979428 DOI: doi:10.1038/s41477-025-01923-z ]
- Water (18 Da, Ligand)
- Cyclic nucleotide-gated ion channel 1 (83 kDa, Protein from Arabidopsis thaliana)
- Structure of cngc1 in gdn (Complex from Arabidopsis thaliana)
- Calcium ion (40 Da, Ligand)
Curved structure of mPIEZO1-S2472E
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2025) 113 pp. 590- [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- S2472e-curved structure (Complex from Mus musculus)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
Flattened structure of mPIEZO1-S2472E
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2025) 113 pp. 590- [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- S2472e-intermediate structure (Complex from Mus musculus)
Berg A, Berntsson RP, Barandun J
PLoS One (2024) 19 pp. e0301951-e0301951 [ DOI: doi:10.1371/journal.pone.0301951 Pubmed: 39038013 ]
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j7m
Q-score: 0.53
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Cholesterol (386 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment) (90 kDa, Protein from Aequorea victoria)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)