Cryo-EM structure of the human TACAN channel in a closed state
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 7f6v
Q-score: 0.406
Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y
Cell Rep (2022) 38 pp. 110445-110445 [ Pubmed: 35235791 DOI: doi:10.1016/j.celrep.2022.110445 ]
- Ion channel tacan (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of the human tacan channel in a closed state (Cellular component from Homo sapiens)
Human TRPM2 ion channel in amphipol (apo state)
To Be Published
Cryo-EM structure of human TMEM120A
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7n7p
Q-score: 0.508
Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y
eLife (2021) 10 [ Pubmed: 34374645 DOI: doi:10.7554/eLife.71220 ]
- Ion channel tacan (42 kDa, Protein from Homo sapiens)
- Human tmem120a with coa (Complex from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 7cfs
Q-score: 0.483
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
eLife (2020) 9 [ Pubmed: 32915133 DOI: doi:10.7554/eLife.57096 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Acid-sensing ion channel 1 (54 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hasic1a (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7cft
Q-score: 0.436
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
eLife (2020) 9 [ Pubmed: 32915133 DOI: doi:10.7554/eLife.57096 ]
- Mambalgin-1 (6 kDa, Protein from Dendroaspis polylepis polylepis)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hasic1a-mamba1 (Complex from Homo sapiens)
- Acid-sensing ion channel 1 (54 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6lyp
Q-score: 0.455
Li Y, Hu Y, Wang J, Liu X, Zhang W, Sun L
Cell Rep (2020) 30 pp. 4518-4527.e3 [ DOI: doi:10.1016/j.celrep.2020.03.026 Pubmed: 32234484 ]
- Mechanosensitive ion channel protein 1, mitochondrial (53 kDa, Protein from Arabidopsis thaliana)
- Wild type of atmsl1 (350 kDa, Complex from Arabidopsis thaliana)
Cryo-EM Structure of the Mammalian Tactile Channel Piezo2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6kg7
Q-score: 0.437
Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B
Nature (2019) 573 pp. 225-229 [ DOI: doi:10.1038/s41586-019-1505-8 Pubmed: 31435011 ]
- Homo-trimer of piezo2 (1 MDa, Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 2 (325 kDa, Protein from Mus musculus)
Cryo-EM structure of full length TRPV5 in nanodisc
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6o1p
Q-score: 0.478
Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J
PNAS (2019) 116 pp. 8869-8878 [ DOI: doi:10.1073/pnas.1820323116 Pubmed: 30975749 ]
Human TRPM2 ion channel in apo state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6mix
Q-score: -0.001