Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8yfc
Q-score: 0.288
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
eLife (2024) [ DOI: doi:10.7554/eLife.101923.2 ]
- Myod family inhibitor domain-containing protein (25 kDa, Protein from Homo sapiens)
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (287 kDa, Protein from Homo sapiens)
- Human piezo1-a1988v-mdfic (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8zu3
Q-score: 0.308
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
eLife (2024) [ DOI: doi:10.7554/eLife.101923.2 ]
- Myod family inhibitor domain-containing protein (25 kDa, Protein from Homo sapiens)
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Human piezo1 (Complex from Homo sapiens)
- Piezo-type mechanosensitive ion channel component 1 (287 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j7m
Q-score: 0.53
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Cholesterol (386 Da, Ligand)
- Ion channel (Complex from Homo sapiens)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment) (90 kDa, Protein from Aequorea victoria)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j7h
Q-score: 0.448
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Ion channel (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 5.5
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8i47
Q-score: 0.519
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8i48
Q-score: 0.547
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5
Resolution: 2.6476 Å
EM Method: Single-particle
Fitted PDBs: 8jj3
Q-score: 0.624
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8wcr
Q-score: 0.625
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
ELIC with Propylamine in spNW15 nanodiscs with 2:1:1 POPC:POPE:POPG
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8twz
Q-score: 0.53
Dalal V, Arcario MJ, Petroff 2nd JT, Tan BK, Dietzen NM, Rau MJ, Fitzpatrick JAJ, Brannigan G, Cheng WWL
Nat Commun (2024) 15 pp. 25-25 [ DOI: doi:10.1038/s41467-023-44366-w Pubmed: 38167383 ]