Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8yfc
Q-score: 0.288
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
eLife (2024) [ DOI: doi:10.7554/eLife.101923.2 ]
- Myod family inhibitor domain-containing protein (25 kDa, Protein from Homo sapiens)
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (287 kDa, Protein from Homo sapiens)
- Human piezo1-a1988v-mdfic (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8zu3
Q-score: 0.308
Shan Y, Guo X, Zhang M, Chen M, Li Y, Zhang MF, Pei D
eLife (2024) [ DOI: doi:10.7554/eLife.101923.2 ]
- Myod family inhibitor domain-containing protein (25 kDa, Protein from Homo sapiens)
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Human piezo1 (Complex from Homo sapiens)
- Piezo-type mechanosensitive ion channel component 1 (287 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j7h
Q-score: 0.448
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Ion channel (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 5.5
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8i47
Q-score: 0.519
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8i48
Q-score: 0.547
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5
Resolution: 2.6476 Å
EM Method: Single-particle
Fitted PDBs: 8jj3
Q-score: 0.624
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8wcr
Q-score: 0.625
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S
Nat Commun (2024) 15 pp. 2967-2967 [ DOI: doi:10.1038/s41467-024-47370-w Pubmed: 38580666 ]
- Proton-gated ion channel (35 kDa, Protein from Gloeobacter violaceus)
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pentameric ligand-gated ion channel (Complex from Gloeobacter violaceus)
ELIC with Propylamine in spNW15 nanodiscs with 2:1:1 POPC:POPE:POPG
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8twz
Q-score: 0.53
Dalal V, Arcario MJ, Petroff 2nd JT, Tan BK, Dietzen NM, Rau MJ, Fitzpatrick JAJ, Brannigan G, Cheng WWL
Nat Commun (2024) 15 pp. 25-25 [ DOI: doi:10.1038/s41467-023-44366-w Pubmed: 38167383 ]
ELIC5 with cysteamine in 2:1:1 POPC:POPE:POPG nanodisc in open conformation
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8vuw
Q-score: 0.538
Petroff JT, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Henin J, Brannigan G, Cheng WWL
Nat Commun (2022) 13 pp. 7017- [ Pubmed: 36385237 DOI: doi:10.1038/s41467-022-34813-5 ]
- 2-amino-ethanethiol (77 Da, Ligand)
- Erwinia chrysanthemi ligand-gated ion channel (37 kDa, Protein from Dickeya chrysanthemi)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Elic5 (p254g/c300s/v261y/g319f/i320f) with cysteamine in 2:1:1 popc:pope:popg nanodisc (Complex from Dickeya chrysanthemi)