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Tissue biology and disease modelling

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Structural biology

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Structural biology

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Hinxton

EMBL-EBI: European Bioinformatics Institute

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Epigenetics and neurobiology

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sample_name:"Isoform 2 of NEDD8 ultimate buster 1"

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EMD-47719

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Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt5 at top of spiral staircase

Release date: Dec. 4, 2024
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9e8g
Q-score: 0.43

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
Magnesium ion (24 Da, Ligand)
Adenosine-5'-diphosphate (427 Da, Ligand)
Substrate peptide (1 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1, fat10 and txnl1 (2 MDa, Complex from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

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EMD-47720

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Human proteasome in resting state conformation bound to TXNL1 in backward conformation

Release date: Dec. 4, 2024
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9e8h
Q-score: 0.471

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (7 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1, fat10 and txnl1 (2 MDa, Complex from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-47721

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Human proteasome in resting state conformation bound to TXNL1 in Forward conformation

Release date: Dec. 4, 2024
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 9e8i
Q-score: 0.482

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1, fat10 and txnl1 (2 MDa, Complex from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-47722

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Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt1 at top of spiral staircase

Release date: Dec. 4, 2024
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9e8j
Q-score: 0.375

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Substrate peptide (1 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1, fat10 and txnl1 (2 MDa, Complex from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-47724

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Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt4 at top of spiral staircase

Release date: Dec. 4, 2024
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 9e8l
Q-score: 0.27

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Substrate peptide (1 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1, fat10 and txnl1 (2 MDa, Complex from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-47725

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Nub1/Fat10-processing human 26S proteasome bound to Txnl1 with Rpt3 at top of spiral staircase

Release date: Dec. 4, 2024
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 9e8n
Q-score: 0.318

Arkinson C, Gee CL, Zhang Z, Dong KC, Martin A

bioRxiv (2024) [ DOI: doi:10.1101/2024.11.08.622731 Pubmed: 39574680 ]

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
Thioredoxin-like protein 1 (32 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
Substrate (869 Da, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1 and fat 10 rpt3 at the top (2 MDa, Complex from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

EMD-42507

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Nub1/Fat10-processing human 26S proteasome

Release date: Nov. 6, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8usc
Q-score: 0.435

Arkinson C, Dong KC, Gee CL, Costello SM, Marqusee S, Martin A

To Be Published

Sample:

26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
26s proteasome regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
Adenosine-5'-diphosphate (427 Da, Ligand)
Magnesium ion (24 Da, Ligand)
Substrate peptide (1 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
Human 26s proteasome complexed with nub1 and fat 10 (2 MDa, Complex from Homo sapiens)
26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 14 (46 kDa, Protein from Homo sapiens)
Zinc ion (65 Da, Ligand)
26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
Isoform 2 of nedd8 ultimate buster 1 (69 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
26s proteasome complex subunit sem1 (8 kDa, Protein from Homo sapiens)
Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
Adenosine-5'-triphosphate (507 Da, Ligand)

[Show more]

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Showing 1 - 7 of 7. Page 1 of 1

Display: Statistics

Download

Select database:

EMDB [7]

Format:

Select the script type:

Shell (Unix-based) Batch (Windows-based)

Preview first 10

Field: