Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9crs
Q-score: 0.509
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-gamma2-beta2-alpha2 assembly
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 9crv
Q-score: 0.471
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta3-alpha1-beta2-alpha2-gamma2 assembly
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9csb
Q-score: 0.437
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9ct0
Q-score: 0.446
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta3-alpha2-gamma2 assembly
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 9ctj
Q-score: 0.367
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta2-alpha3-gamma2 assembly
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 9ctp
Q-score: 0.391
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-3 (52 kDa, Protein from Homo sapiens)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-gamma2-beta1-alpha2 assembly
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 9ctv
Q-score: 0.43
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-1 (51 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Native human GABAA receptor of beta3-alpha1-gamma2-beta3-alpha2 assembly
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9cx7
Q-score: 0.467
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Kappa fab_1f4 light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native human GABAA receptor of beta2-alpha1-beta3-alpha1-gamma2 assembly
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 9cxa
Q-score: 0.497
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Native gabaa receptor purified from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Homo sapiens)
- Kappa fab_1f4 light chain (28 kDa, Protein from Mus musculoides)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Homo sapiens)
Native human GABAA receptor of beta2-alpha1-beta1-alpha2-gamma2 assembly
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 9cxb
Q-score: 0.463
Zhou J, Noviello CM, Teng J, Moore H, Lega B, Hibbs RE
Nature (2025) [ DOI: doi:10.1038/s41586-024-08454-1 Pubmed: 39843743 ]
- Kappa fab_1f4 light chain (23 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Native gabaa receptor from human brain (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-2 (48 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (50 kDa, Protein from Homo sapiens)
- Igg2b fab_1f4 heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-1 (51 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)