Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5oam
Q-score: 0.255
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin, alpha (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker without nucleotide (Complex)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tublin, beta (Complex from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Taxol (853 Da, Ligand)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 5ocu
Q-score: 0.26
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin, alpha (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with amppnp (Complex)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Taxol (853 Da, Ligand)
- Tubulin, beta (Complex from Sus scrofa)
Molecular basis of human kinesin-8 function and inhibition
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Tubulin beta chain (Complex from sus scrofa)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin alpha chain (Complex from Bos taurus)
- 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene (297 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Taxol (853 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with its specific inhibitor btb-1 (Complex)