Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ DOI: doi:10.1038/s41467-024-55361-0 Pubmed: 39747030 ]
- L-dopamine (153 Da, Ligand)
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
Human VMAT2 in complex with dopamine
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wre
Q-score: 0.572
Im D, Jormakka M, Juge N, Kishikawa JI, Kato T, Sugita Y, Noda T, Uemura T, Shiimura Y, Miyaji T, Asada H, Iwata S
Nat Commun (2024) 15 pp. 7661-7661 [ DOI: doi:10.1038/s41467-024-51960-z Pubmed: 39284862 ]
- Fabl (24 kDa, Protein from Mus musculus)
- Synaptic vesicular amine transporter (55 kDa, Protein from Homo sapiens)
- Vmat2-fab0801 complex apo state (90 kDa, Complex from Homo sapiens)
- Fabh (36 kDa, Protein from Mus musculus)
- L-dopamine (153 Da, Ligand)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Human drd2 in complex with heterotrimeric g protein goa (k46e), scfv16, and dopamine (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Escherichia coli)
- L-dopamine (153 Da, Ligand)
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Human drd2 in complex with heterotrimeric g protein goa (k46e) and dopamine (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hfg
Q-score: 0.442
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8jtb
Q-score: 0.573
Wu D, Yu Z, Chen Q, Zhao J, Huang B, Wang Y, Su J, Li N, Jiang D, Zhao Y
Cell Res (2024) 34 pp. 586-589 [ DOI: doi:10.1038/s41422-024-00974-9 Pubmed: 38777861 ]
- Synaptic vesicular amine transporter (49 kDa, Protein from Homo sapiens)
- Transporterc (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
VMAT1 dimer with dopamine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgi
Q-score: 0.396
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- L-dopamine (153 Da, Ligand)
- Reserpine (608 Da, Ligand)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 dimer with dopamine and reserpine (105 kDa, Complex from Homo sapiens)
Cryo-EM structure of dopamine receptor 1 and mini-Gs complex with dopamine bound
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f0t
Q-score: 0.498
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- Cryo-em structure of dopamine receptor 1 and mini-gs complex with dopamine bound (Complex from Homo sapiens)
- Nanobody35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex with Nb35
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7f1o
Q-score: 0.506
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gdp-bound dopamine receptor 1 and mini-gs complex with nb35 (Complex from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)