Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ Pubmed: 39747030 DOI: doi:10.1038/s41467-024-55361-0 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Human drd2 in complex with heterotrimeric g protein goa (k46e), scfv16, and dopamine (120 kDa, Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Human drd2 in complex with heterotrimeric g protein goa (k46e) and dopamine (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hfg
Q-score: 0.442
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ Pubmed: 39048818 DOI: doi:10.1038/s41586-024-07719-z ]
- Net (110 kDa, Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
VMAT1 dimer with dopamine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgi
Q-score: 0.396
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 dimer with dopamine and reserpine (105 kDa, Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Reserpine (608 Da, Ligand)
Cryo-EM structure of dopamine receptor 1 and mini-Gs complex with dopamine bound
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f0t
Q-score: 0.498
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- Nanobody35 (17 kDa, Protein from synthetic construct)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Cryo-em structure of dopamine receptor 1 and mini-gs complex with dopamine bound (Complex from Homo sapiens)
Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex with Nb35
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7f1o
Q-score: 0.506
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- L-dopamine (153 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cryo-em structure of the gdp-bound dopamine receptor 1 and mini-gs complex with nb35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex without Nb35
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7f1z
Q-score: 0.46
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- L-dopamine (153 Da, Ligand)
- Cryo-em structure of the gdp-bound dopamine receptor 1 and mini-gs complex without nb35 (Complex from Homo sapiens)
Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex with Nb35
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7f23
Q-score: 0.456
Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S
Sci Adv (2022) 8 pp. eabo4158-eabo4158 [ DOI: doi:10.1126/sciadv.abo4158 Pubmed: 35687690 ]
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cryo-em structure of the gtp-bound dopamine receptor 1 and mini-gs complex with nb35 (Complex from Homo sapiens)
Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7x2f
Q-score: 0.471
Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S
Nat Commun (2022) 13 pp. 3186-3186 [ DOI: doi:10.1038/s41467-022-30929-w Pubmed: 35676276 ]
- Nanobody35 (17 kDa, Protein from synthetic construct)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Nanobody35 (Complex)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
- Dopamine-ly3154207-bound d1r-minigs (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of the dopamine-ly3154207-bound d1r-minigs complexthe (Complex from Homo sapiens)