Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ Pubmed: 39747030 DOI: doi:10.1038/s41467-024-55361-0 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8jtb
Q-score: 0.573
Wu D, Yu Z, Chen Q, Zhao J, Huang B, Wang Y, Su J, Li N, Jiang D, Zhao Y
Cell Res (2024) 34 pp. 586-589 [ DOI: doi:10.1038/s41422-024-00974-9 Pubmed: 38777861 ]
- Synaptic vesicular amine transporter (49 kDa, Protein from Homo sapiens)
- Transporterc (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
VMAT1 dimer with dopamine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgi
Q-score: 0.396
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Complex of vmat1 dimer with dopamine and reserpine (105 kDa, Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Reserpine (608 Da, Ligand)
Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7pim
Q-score: 0.213
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- L-dopamine (153 Da, Ligand)
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Regulatory domain alpha-helix (1 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase lacking the first 35 residues in complex with its inhibitor dopamine (Complex from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6zn2
Q-score: 0.232
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- L-dopamine (153 Da, Ligand)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Ser-leu-ile-glu-asp-ala-arg-lys-glu-arg-glu-ala-ala-val-ala-ala-ala-ala (1 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6zvp
Q-score: 0.22
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Fe (iii) ion (55 Da, Ligand)
- Tyrosine 3-monooxygenase (51 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Tyrosine hydroxylase in complex with dopamine (Complex from Homo sapiens)