Cryo-EM structure of the human 55S mitoribosome with Tigecycline
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k2a
Q-score: 0.545
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Small ribosomal subunit protein us14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs6m (14 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17m (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms27 (47 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us12m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms25 (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs18m (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms39 (78 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein ms23 (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs1m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5m (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3m (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms26 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms37 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10m (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs16m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein ms22 (41 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- 55s mitoribosome with tigecycline (Complex from Homo sapiens)
- Small ribosomal subunit protein ms31 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms33 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms34 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9m (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms35 (36 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms29 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms40 (29 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs21m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with Tigecycline
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8k2b
Q-score: 0.477
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- 4'-phosphopantetheine (358 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Mitochondrial ribosome and complex i assembly factor altmief1 (8 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- 55s mitoribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xt0
Q-score: 0.434
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms29 (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs21m (10 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein ms37 (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9m (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs1m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs18m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms35 (36 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us7m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms26 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms23 (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms31 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms22 (41 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms40 (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms33 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs16m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us3m (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5m (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms34 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17m (14 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Small ribosomal subunit protein ms39 (78 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs6m (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10m (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms25 (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms27 (47 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt1
Q-score: 0.472
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8xt2
Q-score: 0.415
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms29 (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs21m (10 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein ms37 (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9m (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs1m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs18m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms35 (36 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us7m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms26 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms23 (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms31 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms22 (41 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms40 (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms33 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs16m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us3m (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5m (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms34 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17m (14 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Small ribosomal subunit protein ms39 (78 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs6m (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10m (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms25 (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms27 (47 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt3
Q-score: 0.467
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)