The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C1 symmetry
Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EAE, Bruening AS, Nagykery N, Donahoe PK, Pepin D, Thompson TB
PNAS (2025) 122 pp. e2418088122-e2418088122 [ Pubmed: 39805014 DOI: doi:10.1073/pnas.2418088122 ]
- Muellerian-inhibiting factor (11 kDa, Protein from Homo sapiens)
- 6e11 antibody kappa light chain (23 kDa, Protein from Mus musculus)
- Fab-bound amh procomplex (240 kDa, Complex from Homo sapiens)
- 6e11 antibody igg2a heavy chain (24 kDa, Protein from Mus musculus)
- Muellerian-inhibiting factor (45 kDa, Protein from Homo sapiens)
The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 Fab in C2 symmetry
Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EAE, Bruening AS, Nagykery N, Donahoe PK, Pepin D, Thompson TB
PNAS (2025) 122 pp. e2418088122-e2418088122 [ Pubmed: 39805014 DOI: doi:10.1073/pnas.2418088122 ]
- Muellerian-inhibiting factor (11 kDa, Protein from Homo sapiens)
- 6e11 antibody kappa light chain (23 kDa, Protein from Mus musculus)
- Fab-bound amh procomplex (240 kDa, Complex from Homo sapiens)
- 6e11 antibody igg2a heavy chain (24 kDa, Protein from Mus musculus)
- Muellerian-inhibiting factor (45 kDa, Protein from Homo sapiens)
Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ume
Q-score: 0.462
Feldman J, Ramos ASF, Vu M, Maurer DP, Rosado VC, Lingwood D, Bajic G, Schmidt AG
Sci Immunol (2025) 10 pp. eado9572-eado9572 [ Pubmed: 39854479 DOI: doi:10.1126/sciimmunol.ado9572 ]
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- Fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ha/fab (350 MDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab light chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3
Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, McLellan T, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS, Donald RGK
PLoS Pathog (2025) 21 pp. e1012325-e1012325 [ Pubmed: 39970181 DOI: doi:10.1371/journal.ppat.1012325 ]
- Fab 329-2 light chain (23 kDa, Protein from Mus musculus)
- Ternary complex of e. coli fimh with fabs 329-2 and 454-3 (Complex from Escherichia coli)
- Type 1 fimbrin d-mannose specific adhesin fimh, donor strand complemented with fimg peptide 'triple mutant' (32 kDa, Protein from Escherichia coli)
- Fab 329-2 heavy chain (24 kDa, Protein from Mus musculus)
- Fab 454-3 light chain (23 kDa, Protein from Mus musculus)
- Fab 454-3 heavy chain (23 kDa, Protein from Mus musculus)
GP38-GnH-DS-Gc in the pre-fusion conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b8j
Q-score: 0.474
McFadden E, Monticelli SR, Wang A, Ramamohan AR, Batchelor TG, Kuehne AI, Bakken RR, Tse AL, Chandran K, Herbert AS, McLellan JS
Cell (2025) 188 pp. 303-315.e13 [ Pubmed: 39701101 DOI: doi:10.1016/j.cell.2024.11.008 ]
- Adi-46152 heavy chain (52 kDa, Protein from Homo sapiens)
- Adi-36125 heavy chain (51 kDa, Protein from Homo sapiens)
- Gp38-gnh-ds-gc in complex with adi-46152 and adi-36125 fabs (Complex from Orthonairovirus haemorrhagiae)
- Adi-36125 light chain (26 kDa, Protein from Homo sapiens)
- Glycoprotein n (10 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein c (59 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-46152 light chain (25 kDa, Protein from Homo sapiens)
Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9bdf
Q-score: 0.563
Maurer D, Ferreira Ramos AS, Bajic G, Aaron GS
To Be Published
- Adi-85666 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Hemagglutinin (57 kDa, Protein from Influenza A virus)
- Adi-85666 fab light chain (23 kDa, Protein from Homo sapiens)
- Ha/fab (350 MDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8vym
Q-score: 0.476
Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
PNAS (2024) 121 pp. e2404250121-e2404250121 [ DOI: doi:10.1073/pnas.2404250121 Pubmed: 39231203 ]
- 7h3 fab light chain (22 kDa, Protein from Homo sapiens)
- 1g2 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein b (88 kDa, Protein from Human betaherpesvirus 5)
- Soluble ectodomain of human cytomegalovirus (hcmv) glycoprotein b (gb) in the postfusion conformation in complex with 1g2 and 7h3 fabs (Complex)
- 1g2 fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 7h3 fab heavy chain (25 kDa, Protein from Homo sapiens)
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- Bg505 ds-sosip transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dj85-b.01 fab (Complex from Homo sapiens)
- Dj85-b.01 fab light chain (23 kDa, Protein from Homo sapiens)
- Dj85-b.01 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 ds-sosip dj85-b.01 fab complex (Complex)
- Bg505 ds-sosip surface protein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- Bg505 ds-sosip transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 ds-sosip dj85-c.01 fab complex (Complex)
- Dj85-c.01 fab (Complex from Homo sapiens)
- Bg505 ds-sosip surface protein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Dj85-c.01 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Dj85-c.01 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB
Wang H, Cheng C, Dal Santo JL, Shen CH, Bylund T, Henry AR, Howe CA, Hwang J, Morano NC, Morris DJ, Pletnev S, Roark RS, Zhou T, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changela A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Lee M, Li Y, Lin BC, Liu T, Louder MK, Mandolesi M, Mason RD, McKee K, Nair V, O'Dell S, Olia AS, Ou L, Pegu A, Raju N, Rawi R, Roberts-Torres J, Sarfo EK, Sastry M, Schaub AJ, Schmidt SD, Schramm CA, Schwartz CL, Smith SC, Stephens T, Stuckey J, Teng IT, Todd JP, Tsybovsky Y, Van Wazer DJ, Wang S, Doria-Rose NA, Fischer ER, Georgiev IS, Karlsson Hedestam GB, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD
Cell (2024) 187 pp. 7214-7231.e23 [ Pubmed: 39471811 DOI: doi:10.1016/j.cell.2024.10.003 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dj85-d.01 fab (Complex from Homo sapiens)
- Bg505 ds-sosip glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 ds-sosip dj85-d.01 fab complex (Complex)
- Dj85-d.01 fab light chain (23 kDa, Protein from Homo sapiens)
- Bg505 ds-sosip glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
- Dj85-d.01 fab heavy chain (25 kDa, Protein from Homo sapiens)