BG505 GT1.1 SOSIP in complex with NHP Fabs 12C11 and RM20A3
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sw3
Q-score: 0.564
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12c11 heavy chain variable region (14 kDa, Protein from Macaca)
- 12c11 light chain variable region (11 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip in complex with 12c11 fab and rm20a3 fab (720 kDa, Complex from Macaca)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody FP3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t2e
Q-score: 0.48
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Fp3 heavy chain (11 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Fp3 heavy chain, fp3 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody fp3 (470 kDa, Complex)
- Fp3 light chain (8 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody N289
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8t2f
Q-score: 0.424
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- N289 heavy chain, n289 light chain (Complex from Macaca mulatta)
- N289 light chain (8 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody n289 (470 kDa, Complex)
- N289 heavy chain (9 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF1
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8swv
Q-score: 0.506
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- If1 heavy chain (10 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- If1 heavy chain, if1 light chain (Complex from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody if1 (470 kDa, Complex)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- If1 light chain (8 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF3
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8sww
Q-score: 0.471
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody if3 (470 kDa, Complex)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Nhp polyclonal antibody if3 heavy chain, nhp polyclonal antibody if3 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Nhp polyclonal antibody if3 light chain (9 kDa, Protein from Macaca mulatta)
- Nhp polyclonal antibody if3 heavy chain (9 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody Base4
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8swx
Q-score: 0.43
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Base4 heavy chain (9 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Base4 light chain (7 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Base4 heavy chain, base4 light chain (Complex from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody base4 (470 kDa, Complex)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody FP1
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8sw7
Q-score: 0.444
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Greene KM, Allen JD, Ngo JT, Choe Y, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
bioRxiv (2023) [ Pubmed: 37425865 DOI: doi:10.1101/2023.06.26.545779 ]
- Bg505 boost 2 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Fp1 heavy chain (10 kDa, Protein from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody fp1 (470 kDa, Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fp1 light chain (9 kDa, Protein from Macaca mulatta)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uz4
Q-score: 0.368
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- Sars-cov-2 s 6p in complex with m8a-3 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab heavy chain (25 kDa, Protein from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-3 fab light chain (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab vh and vl domains (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-6
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uz5
Q-score: 0.355
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-6 fab vh and vl domains (Complex from Mus musculus)
- M8a-6 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-6 fab heavy chain (25 kDa, Protein from Mus musculus)
- Sars-cov-2 s 6p in complex with m8a-6 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- M8a-6 fab light chain (23 kDa, Protein from Mus musculus)