Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9hvw
Q-score: 0.384
Peng W, Siborova M, Wu X, Du W, Schulte D, Pronker MF, De Haan CAM, Snijder J
To Be Published
- 131-2a light chain (11 kDa, Protein from Mus musculus)
- 131-2a heavy chain (13 kDa, Protein from Mus musculus)
- Fusion glycoprotein f0 (8 kDa, Protein from human respiratory syncytial virus)
- Fusion glycoprotein f1,probable n-acetylmuramidase (55 kDa, Protein from human respiratory syncytial virus)
- Rsv-f (Complex from human respiratory syncytial virus)
- Rsv-f in postfusion conformation in complex with 131-2a fab (213 MDa, Complex from human respiratory syncytial virus)
- 131-2a fab (Complex from Mus musculus)
Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3
Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, McLellan T, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS, Donald RGK
PLoS Pathog (2025) 21 pp. e1012325-e1012325 [ Pubmed: 39970181 DOI: doi:10.1371/journal.ppat.1012325 ]
- 440-2 fab light chain (24 kDa, Protein from Mus musculus)
- 440-2 fab heavy chain (24 kDa, Protein from Mus musculus)
- 445-3 fab heavy chain (24 kDa, Protein from Mus musculus)
- 445-3 fab light chain (23 kDa, Protein from Mus musculus)
- Type 1 fimbrin d-mannose specific adhesin fimh, donor strand complemented with fimg peptide 'triple mutant' (32 kDa, Protein from Escherichia coli)
- Fimh-dsg tm in complex with fabs 440-2 and 445-3 (Complex)
- Fimh-dsg tm (Complex from Escherichia coli)
- Fab 445-3 (Complex from Mus musculus)
- Fab 440-2 (Complex from Mus musculus)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8znz
Q-score: 0.547
Xu JG, Chen S, He Y, Zhu X, Wang Y, Ye Z, Zhou JC, Wu X, Zhang L, Ren X, Jia H, Yu H, Wei X, Feng Y, Chen X, Cui X, Pan X, Wang S, Xia S, Shang H, Pu Y, Xu W, Li H, Chen Q, Chen Z, Wang M, Yan X, Shi H, Li M, Xia Y, Bellelli R, Dong S, He J, Huang J, Cai CL, Zhu X, Zhan Y, Wan L
Nat Commun (2024) 15 pp. 10872-10872 [ DOI: doi:10.1038/s41467-024-55207-9 Pubmed: 39738003 ]
- Hb0039 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Hb0038 fab light chain (11 kDa, Protein from Homo sapiens)
- Hb0039 fab light chain (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 5'-nucleotidase (58 kDa, Protein from Homo sapiens)
- Cd73 complexed with hb0017 antibody coaktail (630 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Hb0038 fab heavy chain (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9js4
Q-score: 0.434
Liao Y, Ma H, Wang Z, Wang S, He Y, Chang Y, Zong H, Tang H, Wang L, Ke Y, Cai H, Li P, Tang J, Chen H, Drelich A, Peng BH, Hsu J, Tat V, Tseng CK, Song J, Yuan Y, Wu M, Liu J, Yue Y, Zhang X, Wang Z, Yang L, Li J, Ni X, Li H, Xiang Y, Bian Y, Zhang B, Yin H, Dimitrov DS, Gilly J, Han L, Jiang H, Xie Y, Zhu J
PNAS (2025) 122 pp. e2406659122-e2406659122 [ DOI: doi:10.1073/pnas.2406659122 Pubmed: 39908098 ]
- Light chain of 8g3 (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of neutralizing antibody 8g3 in complex with ba.1 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 8g3 (23 kDa, Protein from Homo heidelbergensis)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus)
SFTSV Gn in complex with JK-8/12 Fab
Resolution: 2.37 Å
EM Method: Single-particle
Fitted PDBs: 8zhq
Q-score: 0.505
Zhang S, Shang H, Han S, Li J, Peng X, Wu Y, Yang X, Leng Y, Wang F, Cui N, Xu L, Zhang H, Guo Y, Xu X, Zhang N, Liu W, Li H
Ebiomedicine (2024) 111 pp. 105481-105481 [ Pubmed: 39644769 DOI: doi:10.1016/j.ebiom.2024.105481 ]
- Envelopment polyprotein (38 kDa, Protein from Severe fever with thrombocytopenia syndrome virus)
- Jk-8 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Jk-8 fab light chain (23 kDa, Protein from Homo sapiens)
- Jk-12 fab light chain (22 kDa, Protein from Homo sapiens)
- Jk-12 fab heavy chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of sftsv gn with neutralizing antibodies fab jk-8 and jk-12 (150 kDa, Complex from Homo sapiens)
Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 9iya
Q-score: 0.415
Chang H, Li X, Shen L, Ge X, Hao S, Wu L, Liu S, Liu J, Cherezov V, Hua T
Cell Res (2025) 35 pp. 80-83 [ Pubmed: 39482405 DOI: doi:10.1038/s41422-024-01046-8 ]
- Anti-fab nanobody (13 kDa, Protein from Homo sapiens)
- 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{n}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{h}-quinoline-3-carboxamide (527 Da, Ligand)
- Ternary complex of gpr55 with anti-bril fab and anti-fab nanobody (173 kDa, Complex from Homo sapiens)
- G-protein coupled receptor 55,soluble cytochrome b562 (47 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 329-2 and 454-3
Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, McLellan T, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS, Donald RGK
PLoS Pathog (2025) 21 pp. e1012325-e1012325 [ Pubmed: 39970181 DOI: doi:10.1371/journal.ppat.1012325 ]
- Fab 329-2 light chain (23 kDa, Protein from Mus musculus)
- Ternary complex of e. coli fimh with fabs 329-2 and 454-3 (Complex from Escherichia coli)
- Type 1 fimbrin d-mannose specific adhesin fimh, donor strand complemented with fimg peptide 'triple mutant' (32 kDa, Protein from Escherichia coli)
- Fab 329-2 heavy chain (24 kDa, Protein from Mus musculus)
- Fab 454-3 light chain (23 kDa, Protein from Mus musculus)
- Fab 454-3 heavy chain (23 kDa, Protein from Mus musculus)
Structure of interleukin receptor common gamma chain (IL2Rgamma/CD132) in complex with 2D4
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9jqt
Q-score: 0.555
Yin H, Li L, Feng X, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M, Lu Q
Signal Transduct Target Ther (2024) 9 pp. 323-323 [ DOI: doi:10.1038/s41392-024-02017-6 Pubmed: 39551768 ]
- Cytokine receptor common subunit gamma (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (14 kDa, Protein from Lama glama)
- 2d4-light chain (23 kDa, Protein from Homo sapiens)
- Interleukin receptor common gamma chain (il2rgamma/cd132) in complex with 2d4 (Complex from Homo sapiens)
- 2d4-heavy chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of CCR6 bound by SQA1 and OXM2
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 9d3e
Q-score: 0.499
Wasilko DJ, Gerstenberger BS, Farley KA, Li W, Alley J, Schnute ME, Unwalla RJ, Victorino J, Crouse KK, Ding R, Sahasrabudhe PV, Vincent F, Frisbie RK, Dermenci A, Flick A, Choi C, Chinigo G, Mousseau JJ, Trujillo JI, Nuhant P, Mondal P, Lombardo V, Lamb D, Hogan BJ, Minhas GS, Segala E, Oswald C, Windsor IW, Han S, Rappas M, Cooke RM, Calabrese MF, Berstein G, Thorarensen A, Wu H
Nat Commun (2024) 15 pp. 7574-7574 [ DOI: doi:10.1038/s41467-024-52045-7 Pubmed: 39217154 ]
- Ccr6-bril/fab/nb in complex with sqa1 and oxm2 (120 MDa, Complex from Homo sapiens)
- Human ccr6 (54 kDa, Protein from Homo sapiens)
- Anti-bril fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- N-{[(2r)-4-(bicyclo[1.1.1]pentan-1-yl)-5-oxomorpholin-2-yl]methyl}-1-[4-(trifluoromethyl)phenyl]cyclopropane-1-carboxamide (408 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 4-[[3,4-bis(oxidanylidene)-2-[[(1~{r})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{n},~{n}-dimethyl-3-oxidanyl-pyridine-2-carboxamide (426 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
Cryo-EM structure of CCR6 bound by SQA1 and OXM1
Wasilko DJ, Gerstenberger BS, Farley KA, Li W, Alley J, Schnute ME, Unwalla RJ, Victorino J, Crouse KK, Ding R, Sahasrabudhe PV, Vincent F, Frisbie RK, Dermenci A, Flick A, Choi C, Chinigo G, Mousseau JJ, Trujillo JI, Nuhant P, Mondal P, Lombardo V, Lamb D, Hogan BJ, Minhas GS, Segala E, Oswald C, Windsor IW, Han S, Rappas M, Cooke RM, Calabrese MF, Berstein G, Thorarensen A, Wu H
Nat Commun (2024) 15 pp. 7574-7574 [ DOI: doi:10.1038/s41467-024-52045-7 Pubmed: 39217154 ]
- Ccr6, soluble cytochrome b562 (54 kDa, Protein from Homo sapiens)
- 1-(4-chlorophenyl)-n-{[(2r)-4-(2,3-dihydro-1h-inden-2-yl)-5-oxomorpholin-2-yl]methyl}cyclopropane-1-carboxamide (424 Da, Ligand)
- Anti-bril fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ccr6-bril/fab/nb in complex with sqa1 and oxm1 (120 MDa, Complex from Homo sapiens)
- 4-[[3,4-bis(oxidanylidene)-2-[[(1~{r})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{n},~{n}-dimethyl-3-oxidanyl-pyridine-2-carboxamide (426 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)