Cryo-EM structure of coxsackievirus A16 empty particle in complex with Fab h1A6.2 (local refinement)
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ Pubmed: 39424982 DOI: doi:10.1038/s41564-024-01822-7 ]
- Coxsackievirus a16 (Virus from Coxsackievirus A16)
- The heavy chain of fab h1a6.2 (12 kDa, Protein from Mus musculus)
- Genome polyprotein (26 kDa, Protein from Coxsackievirus A16)
- The fab of h1a6.2 (Complex from Mus musculus)
- Genome polyprotein (27 kDa, Protein from Coxsackievirus A16)
- Coxsackievirus a16 empty particle in complex with fab h1a6.2 (Complex)
- Capsid protein vp1 (33 kDa, Protein from Coxsackievirus A16)
- The light chain of fab h1a6.2 (12 kDa, Protein from Mus musculus)
Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 8A10 (CVB1-A:8A10)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7x35
Q-score: 0.557
Zheng Q, Zhu R, Yin Z, Xu L, Sun H, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y, Cheng T, Li S, Xia N
Cell Host Microbe (2022) 30 pp. 1279-1294.e6 [ DOI: doi:10.1016/j.chom.2022.08.001 Pubmed: 36002016 ]
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- 8a10 light chain (11 kDa, Protein from Mus musculus)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- 8a10 heavy chain (13 kDa, Protein from Mus musculus)
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8iv4
Q-score: 0.506
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ Pubmed: 37470320 DOI: doi:10.1093/procel/pwad040 ]
- Heavy chain of 8h12 (13 kDa, Protein from Mus musculus)
- Light chain of 3e2 (11 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with double nabs 3e2 and 1c4 (Complex)
- Light chain of 8h12 (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nabs 8h12 and 3e2 (Complex from Mus musculus)
- Heavy chain of 3e2 (13 kDa, Protein from Mus musculus)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8iv5
Q-score: 0.494
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ Pubmed: 37470320 DOI: doi:10.1093/procel/pwad040 ]
- Heavy chain of 8h12 (13 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with 8h12 (Complex)
- Light chain of 8h12 (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Nabs 8h12,1c4 (Complex from Mus musculus)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 1c4 (13 kDa, Protein from Mus musculus)
- Light chain of 1c4 (11 kDa, Protein from Mus musculus)
Resolution: 3.92 Å
EM Method: Single-particle
Fitted PDBs: 8iv8
Q-score: 0.444
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ Pubmed: 37470320 DOI: doi:10.1093/procel/pwad040 ]
- Light chain of 3e2 (11 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with double nabs 3e2 and 1c4 (Complex)
- Nabs 3e2 and 1c4 (Complex from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 3e2 (13 kDa, Protein from Mus musculus)
- Heavy chain of 1c4 (13 kDa, Protein from Mus musculus)
- Light chain of 1c4 (11 kDa, Protein from Mus musculus)
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 8iva
Q-score: 0.46
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ Pubmed: 37470320 DOI: doi:10.1093/procel/pwad040 ]
- Nab xma01 (Complex from Homo sapiens)
- Light chain of 3e2 (11 kDa, Protein from Mus musculus)
- Nab 3e2 (Complex from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with double nabs 3e2 and 1c4 (Complex)
- Heavy chain of xma01 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of xma01 (11 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 3e2 (13 kDa, Protein from Mus musculus)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yve
Q-score: 0.47
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Omicron ba.4/5 sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Th027 fab (Complex from Homo sapiens)
- Th027 fab light chain (11 kDa, Protein from Homo sapiens)
- Omicron ba.5 sars-cov-2 s in complex with th027 fab (Complex)
- Th027 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH027 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvf
Q-score: 0.518
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th027 fab (Complex from Homo sapiens)
- Th027 fab light chain (11 kDa, Protein from Homo sapiens)
- Omicron ba.5 sars-cov-2 s rbd in complex with th027 fab (Complex)
- Th027 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yvg
Q-score: 0.384
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th132 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Th132 fab light chain (11 kDa, Protein from Homo sapiens)
Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH132 Fab
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7yvh
Q-score: 0.401
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z
Nat Commun (2023) 14 pp. 3537-3537 [ DOI: doi:10.1038/s41467-023-39267-x Pubmed: 37322000 ]
- Th027 fab (Complex from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s in complex with th027 fab (Complex)
- Th132 fab heavy chain (12 kDa, Protein from Homo sapiens)
- Omicron ba.4/5 sars-cov-2 s (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Th132 fab light chain (11 kDa, Protein from Homo sapiens)