Cryo-EM structure of the SFV009 3G01 Fab in complex with A/California/04/2009
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9dm0
Q-score: 0.511
Lin TH, Lee CD, Fernandez-Quintero ML, Ferguson JA, Han J, Zhu X, Yu W, Guthmiller JJ, Krammer F, Wilson PC, Ward AB, Wilson IA
Nat Commun (2025) 16 pp. 1268-1268 [ DOI: doi:10.1038/s41467-025-56496-4 Pubmed: 39894881 ]
- Hemagglutinin (35 kDa, Protein from Influenza A virus (A/California/04/2009(H1N1)))
- Hemagglutinin ha1/2 (Complex)
- Fab (Complex)
- Fab light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ca09 homotrimer bound to anchor fab (Complex from Homo sapiens)
- Hemagglutinin (26 kDa, Protein from Influenza A virus (A/California/04/2009(H1N1)))
- Fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of LAT1-CD98hc-Fab170 in complex with JPH203, consensus map
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 8kdd
Q-score: 0.432
Lee Y, Jin C, Ohgaki R, Xu M, Ogasawara S, Warshamanage R, Yamashita K, Murshudov G, Nureki O, Murata T, Kanai Y
Nat Commun (2025) 16 pp. 1635-1635 [ Pubmed: 39952931 DOI: doi:10.1038/s41467-025-56903-w ]
- Fab170 (Complex from Mus musculus)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
- Nanvuranlat (472 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lat1-cd98hc (Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
Structure of LAT1-CD98hc-Fab170 in complex with BCH, consensus map
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8kdg
Q-score: 0.424
Lee Y, Jin C, Ohgaki R, Xu M, Ogasawara S, Warshamanage R, Yamashita K, Murshudov G, Nureki O, Murata T, Kanai Y
Nat Commun (2025) 16 pp. 1635-1635 [ Pubmed: 39952931 DOI: doi:10.1038/s41467-025-56903-w ]
- Fab170 (Complex from Mus musculus)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
- (1~{s},2~{r},4~{r})-2-azanylbicyclo[2.2.1]heptane-2-carboxylic acid (155 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Lat1-cd98hc-fab170 (173 kDa, Complex)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lat1-cd98hc (Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
Structure of apo inward-open LAT1-CD98hc-Fab170 in nanodisc, consensus map
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8kdi
Q-score: 0.43
Lee Y, Jin C, Ohgaki R, Xu M, Ogasawara S, Warshamanage R, Yamashita K, Murshudov G, Nureki O, Murata T, Kanai Y
Nat Commun (2025) 16 pp. 1635-1635 [ Pubmed: 39952931 DOI: doi:10.1038/s41467-025-56903-w ]
- Fab170 (Complex from Mus musculus)
- Fab170 light chain (24 kDa, Protein from Mus musculus)
- Lat1-cd98hc-fab170 (Complex)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Fab170 heavy chain (24 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lat1-cd98hc (Complex from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tmb
Q-score: 0.403
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Magnesium ion (24 Da, Ligand)
- Cora in complex with conformation-specific sab c12 and 20 mm mgcl2 (Complex from Thermotoga maritima)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Sab c12 light chain (23 kDa, Protein from Homo sapiens)
- Sab c12 heavy chain (25 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tmc
Q-score: 0.458
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Sab c12 heavy chain (25 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Cora in complex with conformation-specific sab c12 and 20 mm mgcl2 (Complex from Thermotoga maritima)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Sab c12 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tmd
Q-score: 0.49
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Magnesium ion (24 Da, Ligand)
- Sab c18 light chain (23 kDa, Protein from Homo sapiens)
- Sab c18 heavy chain (25 kDa, Protein from Homo sapiens)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Cora in complex with conformation-specific sab c18 and 100 um mgcl2 (Complex from Thermotoga maritima)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tme
Q-score: 0.452
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Magnesium ion (24 Da, Ligand)
- Sab c18 light chain (23 kDa, Protein from Homo sapiens)
- Sab c18 heavy chain (25 kDa, Protein from Homo sapiens)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Cora in complex with conformation-specific sab c18 and 100 um mgcl2 (Complex from Thermotoga maritima)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tmf
Q-score: 0.427
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Magnesium ion (24 Da, Ligand)
- Sab c18 light chain (23 kDa, Protein from Homo sapiens)
- Sab c18 heavy chain (25 kDa, Protein from Homo sapiens)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Cora in complex with conformation-specific sab c18 and 100 um mgcl2 (Complex from Thermotoga maritima)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tmg
Q-score: 0.496
Erramilli SK, Nosol K, Pietrzak-Lichwa K, Li T, Dutka P, Hou J, Zhao M, Perozo E, Kossiakoff AA
To Be Published
- Magnesium ion (24 Da, Ligand)
- Sab c18 light chain (23 kDa, Protein from Homo sapiens)
- Sab c18 heavy chain (25 kDa, Protein from Homo sapiens)
- Cobalt/magnesium transport protein cora (44 kDa, Protein from Thermotoga maritima)
- Cora in complex with conformation-specific sab c18 and 100 um mgcl2 (Complex from Thermotoga maritima)