Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8w0e
Q-score: 0.445
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- In vitro loaded, human mcm2-7 single hexamer on dsdna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0f
Q-score: 0.501
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- In vitro loaded, human mcm2-7 double hexamer on dsdna (Complex from Homo sapiens)
- Dna (47-mer) (14 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna (47-mer) (14 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human MCM2-7 dimer
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0g
Q-score: 0.268
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Human mcm2-7 dimer (Complex from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human MCM2-7 heterohexamer
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8w0i
Q-score: 0.367
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Human mcm2-7 heterohexamer (Complex from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9caq
Q-score: 0.396
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna (44-mer) (13 kDa, DNA from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna (44-mer) (13 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- In vitro loaded, human mcm2-7 double hexamer on dsdna (formed by dimerization of independently loaded mcm2-7 single hexamers) (Complex from Homo sapiens)