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sample_name:"Mediator of RNA polymerase II transcription subunit 30"
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Structure of human transcriptional Mediator complex

Release date: Oct. 9, 2024
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 8tqw
Q-score: 0.111

Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL

Mol Cell (2024) 84 pp. 3932-3949.e10 [ DOI: doi:10.1016/j.molcel.2024.09.001 Pubmed: 39321804 ]

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The IDRc bound human core Mediator complex

Release date: Oct. 9, 2024
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8trh
Q-score: 0.317

Chao TC, Chen SF, Kim HJ, Tang HC, Tseng HC, Xu A, Palao 3rd L, Khadka S, Li T, Huang MF, Lee DF, Murakami K, Boyer TG, Tsai KL

Mol Cell (2024) 84 pp. 3932-3949.e10 [ DOI: doi:10.1016/j.molcel.2024.09.001 Pubmed: 39321804 ]

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Atomic model of the mammalian mouse Mediator complex with CKM module

Release date: July 3, 2024
Resolution: 4.83 Å
EM Method: Single-particle
Fitted PDBs: 8t1l
Q-score: 0.247

Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ

Mol Cell (2024) 84 pp. 2648-2664.e10 [ DOI: doi:10.1016/j.molcel.2024.06.006 Pubmed: 38955181 ]

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CryoEM structure of TR-TRAP

Release date: July 3, 2024
Resolution: 4.66 Å
EM Method: Single-particle
Fitted PDBs: 8t9d
Q-score: 0.215

Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ

Mol Cell (2024) 84 pp. 2648-2664.e10 [ DOI: doi:10.1016/j.molcel.2024.06.006 Pubmed: 38955181 ]

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Atomic model of the mammalian Mediator complex with MED26 subunit

Release date: June 12, 2024
Resolution: 4.68 Å
EM Method: Single-particle
Fitted PDBs: 8t1i
Q-score: 0.238

Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ

Mol Cell (2024) 84 pp. 2648-2664.e10 [ DOI: doi:10.1016/j.molcel.2024.06.006 Pubmed: 38955181 ]

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PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state

Release date: Nov. 2, 2022
Resolution: 5.04 Å
EM Method: Single-particle
Fitted PDBs: 8gxq
Q-score: 0.084

Chen X, Wang X, Liu W, Ren Y, Qu X, Li J, Yin X, Xu Y

Science (2022) 378 pp. 62-68 [ DOI: doi:10.1126/science.abn8131 Pubmed: 36201575 ]

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PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state

Release date: Nov. 2, 2022
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8gxs
Q-score: 0.093

Chen X, Wang X, Liu W, Ren Y, Qu X, Li J, Yin X, Xu Y

Science (2022) 378 pp. 62-68 [ DOI: doi:10.1126/science.abn8131 Pubmed: 36201575 ]

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TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)

Release date: May 26, 2021
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 7ena
Q-score: 0.168

Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y

Science (2021) 372 [ Pubmed: 33958484 DOI: doi:10.1126/science.abg0635 ]

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TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)

Release date: May 26, 2021
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 7enc
Q-score: 0.103

Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y

Science (2021) 372 [ Pubmed: 33958484 DOI: doi:10.1126/science.abg0635 ]

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Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B)

Release date: May 19, 2021
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7enj
Q-score: 0.17

Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y

Science (2021) 372 [ Pubmed: 33958484 DOI: doi:10.1126/science.abg0635 ]

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