Cryo-EM structure of membrane transporter with inhibitor G
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Human mpc with gw604714x (Complex from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Nanobody (16 kDa, Protein from synthetic construct)
- (5e)-5-({(5p)-5-[6-(4-acetylpiperazin-1-yl)-3-nitropyridin-2-yl]-2-fluorophenyl}methylidene)-1,3-thiazolidine-2,4-dione (471 Da, Ligand)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human MPC in complex with UK5099 in LMNG
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- (e)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid (288 Da, Ligand)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Nanobody (16 kDa, Protein from synthetic construct)
- Human mpc in lmng with uk5099 (Complex from Homo sapiens)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human MPC with pyruvate
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- Pyruvic acid (88 Da, Ligand)
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Human mpc with pyruvate (Complex from Homo sapiens)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Nanobody (16 kDa, Protein from synthetic construct)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human MPC in complex with UK5099 in nanodiscs
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- Human mpc in nanodiscs with uk5099 (Complex from Homo sapiens)
- (e)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid (288 Da, Ligand)
- Nanobody (16 kDa, Protein from synthetic construct)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human MPC in complex with AKOS005153046
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- Human mpc with akos (Complex from Homo sapiens)
- (~{e})-2-cyano-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enoic acid (284 Da, Ligand)
- Nanobody (16 kDa, Protein from synthetic construct)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)