Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8jvh
Q-score: 0.422
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8jw4
Q-score: 0.421
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8jwf
Q-score: 0.354
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8jwg
Q-score: 0.335
Cryo-EM structure of the outward-facing Plasmodium falciparum multidrug resistance protein 1
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8jwi
Q-score: 0.504
Si K, He X, Chen L, Zhang A, Guo C, Li M
PNAS (2023) 120 pp. e2219905120-e2219905120 [ DOI: doi:10.1073/pnas.2219905120 Pubmed: 37527341 ]
- Plasmodium falciparum multidrug resistance protein 1 in the outward-facing conformation (Complex from Plasmodium falciparum (isolate 3D7))
- Magnesium ion (24 Da, Ligand)
- Multidrug resistance protein 1 (158 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Adenosine-5'-triphosphate (507 Da, Ligand)
Bovine multidrug resistance protein 1 (MRP1) bound to cyclic peptide inhibitor 1 (CPI1)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8f4b
Q-score: 0.46
Pietz HL, Abbas A, Johnson ZL, Oldham ML, Suga H, Chen J
PNAS (2023) 120 pp. e2220012120-e2220012120 [ DOI: doi:10.1073/pnas.2220012120 Pubmed: 36893260 ]
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7o9w
Q-score: 0.321
Urgaonkar S, Nosol K, Said AM, Nasief NN, Bu Y, Locher KP, Lau JYN, Smolinski MP
J Med Chem (2022) 65 pp. 191-216 [ Pubmed: 34928144 DOI: doi:10.1021/acs.jmedchem.1c01272 ]
- Multidrug resistance protein 1 (Complex from Homo sapiens)
- Uic2 fab-fragment light chain (24 kDa, Protein from Mus musculus)
- Fab (Complex from Mus musculus)
- Multidrug resistance protein 1 (141 kDa, Protein from Homo sapiens)
- ~{n}-[2-[2-[4-[2-(6,7-dimethoxy-3,4-dihydro-1~{h}-isoquinolin-2-yl)ethyl]phenyl]-1,2,3,4-tetrazol-5-yl]-4,5-dimethoxy-phenyl]-4-oxidanylidene-2,3-dihydrochromene-2-carboxamide (690 Da, Ligand)
- Uic2 fab-fragment heavy chain (24 kDa, Protein from Mus musculus)
- Nanodisc reconstituted human p-glycoprotein in complex with uic2-fab and encequidar (240 kDa, Complex)
Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 7otg
Q-score: 0.091
Barbieri A, Thonghin N, Shafi T, Prince SM, Collins RF, Ford RC
Membranes (Basel) (2021) 11 [ DOI: doi:10.3390/membranes11120923 Pubmed: 34940424 ]
Structure of ABCB1/P-glycoprotein in apo state
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7oti
Q-score: 0.066
Barbieri A, Thonghin N, Shafi T, Prince SM, Collins RF, Ford RC
Membranes (Basel) (2021) 11 [ DOI: doi:10.3390/membranes11120923 Pubmed: 34940424 ]
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7a69
Q-score: 0.381
Nosol K, Romane K, Irobalieva RN, Alam A, Kowal J, Fujita N, Locher KP
PNAS (2020) 117 pp. 26245-26253 [ DOI: doi:10.1073/pnas.2010264117 Pubmed: 33020312 ]
- Mrk16 fab-fragment light chain (24 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Multidrug resistance protein 1 (141 kDa, Protein from Homo sapiens)
- Mrk16 fab-fragment heavy chain (23 kDa, Protein from Mus musculus)
- Vincristine (824 Da, Ligand)
- Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine (240 kDa, Complex from Homo sapiens)