(CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rz7
Q-score: 0.292
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-dna-adp complex (Complex)
- Dna mismatch repair protein (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna_2 (18 kDa, DNA from Homo sapiens)
- Dna_1 (20 kDa, DNA from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from Homo sapiens)
MutSbeta-ATPgS with straight MSH2 clamp
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8rz8
Q-score: 0.349
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta-ATPgS with kinked MSH2 clamp
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8rz9
Q-score: 0.332
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8r7v
Q-score: 0.381
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna_61bp_complement_rev (18 kDa, DNA from Homo sapiens)
- ~{n}-[3-[[2-[[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide (487 Da, Ligand)
- Mutsbeta in complex with the mismatched dna and compound (Complex)
- Magnesium ion (24 Da, Ligand)
- Mutsbeta (Complex from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna_61bp_cag2_loop_fwd (20 kDa, DNA from Homo sapiens)
- Double stranded dna (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
MutSbeta bound to (CAG)2 DNA (canonical form)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8olx
Q-score: 0.397
Lee JH, Thomsen M, Daub H, Thieulin-Pardo G, Steinbacher SC, Sztyler A, Dahiya V, Neudegger T, Dominguez C, Iyer RR, Wilkinson HA, Monteagudo E, Plotnikov NV, Felsenfeld DP, Haque TS, Finley M, Boudet J, Vogt TF, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2023.05.08.539930 ]
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna (21-mer) (6 kDa, DNA from synthetic construct)
- Mutsbeta bound to (cag)2 dna (canonical form) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (27-mer) (8 kDa, DNA from synthetic construct)
DNA-free open form of MutSbeta
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8om5
Q-score: 0.3
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna-free open form of mutsbeta (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
MutSbeta bound to (CAG)2 DNA (open form)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8om9
Q-score: 0.249
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta bound to (cag)2 dna (open form) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna1 (8 kDa, DNA from Homo sapiens)
- Dna2 (6 kDa, DNA from Homo sapiens)
MutSbeta bound to 61bp homoduplex DNA
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8oma
Q-score: 0.177
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna2 (5 kDa, DNA from Homo sapiens)
- Mutsbeta bound to 61bp homoduplex dna (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna1 (5 kDa, DNA from Homo sapiens)
DNA-unbound MutSbeta-ATP complex (bent clamp form)
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8omo
Q-score: 0.318
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna-unbound mutsbeta-atp complex (bent clamp form) (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
DNA-unbound MutSbeta-ATP complex (straight clamp form)
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8omq
Q-score: 0.371
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna-unbound mutsbeta-atp complex (straight clamp form) (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)