(CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8rz7
Q-score: 0.292
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Dna_1 (20 kDa, DNA from Homo sapiens)
- Double stranded dna (Complex from Homo sapiens)
- Dna_2 (18 kDa, DNA from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta-dna-adp complex (Complex)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna mismatch repair protein (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
MutSbeta-ATPgS with straight MSH2 clamp
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8rz8
Q-score: 0.349
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
MutSbeta-ATPgS with kinked MSH2 clamp
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8rz9
Q-score: 0.332
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Mutsbeta-atpgs complex (Complex from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
MutSbeta bound to (CAG)2 DNA (canonical form)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8olx
Q-score: 0.397
Lee JH, Thomsen M, Daub H, Thieulin-Pardo G, Steinbacher SC, Sztyler A, Dahiya V, Neudegger T, Dominguez C, Iyer RR, Wilkinson HA, Monteagudo E, Plotnikov NV, Felsenfeld DP, Haque TS, Finley M, Boudet J, Vogt TF, Prasad BC
bioRxiv (2024) [ DOI: doi:10.1101/2023.05.08.539930 ]
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Mutsbeta bound to (cag)2 dna (canonical form) (Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (27-mer) (8 kDa, DNA from synthetic construct)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna (21-mer) (6 kDa, DNA from synthetic construct)
DNA-free open form of MutSbeta
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8om5
Q-score: 0.3
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Dna-free open form of mutsbeta (Complex from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta bound to (CAG)2 DNA (open form)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8om9
Q-score: 0.249
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Mutsbeta bound to (cag)2 dna (open form) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna1 (8 kDa, DNA from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna2 (6 kDa, DNA from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
MutSbeta bound to 61bp homoduplex DNA
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8oma
Q-score: 0.177
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Mutsbeta bound to 61bp homoduplex dna (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna2 (5 kDa, DNA from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna1 (5 kDa, DNA from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
DNA-unbound MutSbeta-ATP complex (bent clamp form)
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8omo
Q-score: 0.318
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Dna-unbound mutsbeta-atp complex (bent clamp form) (Complex from Homo sapiens)
DNA-unbound MutSbeta-ATP complex (straight clamp form)
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8omq
Q-score: 0.371
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna-unbound mutsbeta-atp complex (straight clamp form) (Complex from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
MutSbeta bound to homoduplex plasmid DNA
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published