Cryo-EM structure of human binary NatC complex with a Bisubstrate inhibitor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rb3
Q-score: 0.52
Deng S, Gardner SM, Gottlieb L, Pan B, Petersson EJ, Marmorstein R
Structure (2023) 31 pp. 166-173.e4 [ DOI: doi:10.1016/j.str.2022.12.008 Pubmed: 36638802 ]
- N-alpha-acetyltransferase 35, natc auxiliary subunit (80 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- N-alpha-acetyltransferase 30 (18 kDa, Protein from Homo sapiens)
- Leucine (131 Da, Ligand)
- Heterotimeric s.pombe natc complex with a bisubstrate inhibitor and inositol hexaphosphate (Complex from Homo sapiens)
- Carboxymethyl coenzyme *a (825 Da, Ligand)
Cryo-EM structure of human ternary NatC complex with a Bisubstrate inhibitor
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7mx2
Q-score: 0.495
Deng S, Gardner SM, Gottlieb L, Pan B, Petersson EJ, Marmorstein R
Structure (2023) 31 pp. 166-173.e4 [ DOI: doi:10.1016/j.str.2022.12.008 Pubmed: 36638802 ]
- Peptide portion of bisubstrate inhibitor (416 Da, Protein from Homo sapiens)
- N-alpha-acetyltransferase 30 (18 kDa, Protein from Homo sapiens)
- N-alpha-acetyltransferase 38, natc auxiliary subunit (13 kDa, Protein from Homo sapiens)
- Bisubstrate inhibitor (Complex from Homo sapiens)
- N-alpha-acetyltransferase 35, natc auxiliary subunit (83 kDa, Protein from Homo sapiens)
- Heterotimeric human natc complex with a bisubstrate inhibitor (114 kDa, Complex)
- Carboxymethyl coenzyme *a (825 Da, Ligand)
- N-alpha-acetyltransferase natc complex (Complex from Homo sapiens)
Cryo-EM structure of S. Pombe NatC complex with a Bisubstrate inhibitor and inositol hexaphosphate
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7l1k
Q-score: 0.567
Deng S, Gottlieb L, Pan B, Supplee J, Wei X, Petersson EJ, Marmorstein R
Structure (2021) 29 pp. 1094- [ DOI: doi:10.1016/j.str.2021.05.003 Pubmed: 34019809 ]
- Inositol hexakisphosphate (660 Da, Ligand)
- N-alpha-acetyltransferase 30 (17 kDa, Protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843))
- N-alpha-acetyltransferase natc, catalytic subunit naa30, auxiliary subunits naa35 and naa38 (Complex from Schizosaccharomyces pombe)
- N-alpha-acetyltransferase 38, natc auxiliary subunit (13 kDa, Protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843))
- N-alpha-acetyltransferase 35, natc auxiliary subunit (80 kDa, Protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843))
- Heterotimeric s.pombe natc complex with a bisubstrate inhibitor and inositol hexaphosphate (Complex)
- Mlgp peptide (416 Da, Protein from Homo sapiens)
- Carboxymethyl coenzyme *a (825 Da, Ligand)
- Coa-ac-mlgp bi-substrate (Complex)