Cryo-EM structure of SNAP-94847-bound MCHR1, S1 state
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8yns
Q-score: 0.476
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
Cryo-EM structure of SNAP-94847-bound MCHR1, S2 state
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8ynt
Q-score: 0.422
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
Cryo-EM structure of human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xdc
Q-score: 0.562
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
Antibody N3-1 bound to RBDs in the up and down conformations
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8tm1
Q-score: 0.543
Goike J, Hsieh CL, Horton AP, Gardner EC, Zhou L, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Xie X, Xia H, Shi PY, Renberg R, Segall-Shapiro TH, Terrace CI, Wu W, Shroff R, Byrom M, Ellington AD, Marcotte EM, Musser JM, Kuchipudi SV, Kapur V, Georgiou G, Weaver SC, Dye JM, Boutz DR, McLellan JS, Gollihar JD
Commun Biol (2023) 6 pp. 1250-1250 [ Pubmed: 38082099 DOI: doi:10.1038/s42003-023-05649-6 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- N3-1 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- N3-1 fab light chain (11 kDa, Protein from Homo sapiens)
- N3-1 fab (Complex from Homo sapiens)
- The complex of n3-1 fab bound to two receptor binding domains of the spike (Complex)
Antibody N3-1 bound to RBD in the up conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tma
Q-score: 0.501
Goike J, Hsieh CL, Horton AP, Gardner EC, Zhou L, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Xie X, Xia H, Shi PY, Renberg R, Segall-Shapiro TH, Terrace CI, Wu W, Shroff R, Byrom M, Ellington AD, Marcotte EM, Musser JM, Kuchipudi SV, Kapur V, Georgiou G, Weaver SC, Dye JM, Boutz DR, McLellan JS, Gollihar JD
Commun Biol (2023) 6 pp. 1250-1250 [ Pubmed: 38082099 DOI: doi:10.1038/s42003-023-05649-6 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The complex of n3-1 fab bound to one receptor binding domain of the spike (Complex)
- N3-1 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- N3-1 fab light chain (11 kDa, Protein from Homo sapiens)
- N3-1 fab (Complex from Homo sapiens)
Antibody N3-1 bound to SARS-CoV-2 spike
Goike J, Hsieh CL, Horton AP, Gardner EC, Zhou L, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Xie X, Xia H, Shi PY, Renberg R, Segall-Shapiro TH, Terrace CI, Wu W, Shroff R, Byrom M, Ellington AD, Marcotte EM, Musser JM, Kuchipudi SV, Kapur V, Georgiou G, Weaver SC, Dye JM, Boutz DR, McLellan JS, Gollihar JD
Commun Biol (2023) 6 pp. 1250-1250 [ Pubmed: 38082099 DOI: doi:10.1038/s42003-023-05649-6 ]
- N3-1 fab heavy chain (Protein from Homo sapiens)
- Complex of n3-1 bound to sars-cov-2 spike (Complex)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- N3-1 (Complex from Homo sapiens)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
- N3-1 fab light chain (Protein from Homo sapiens)
Antibody N3-1 bound to SARS-CoV-2 spike
Goike J, Hsieh C-L, McLellan JS, Gollihar JD
To Be Published