Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8fvu
Q-score: 0.412
Matico RE, Yu X, Miller R, Somani S, Ricketts MD, Kumar N, Steele RA, Medley Q, Berger S, Faustin B, Sharma S
Nat Struct Mol Biol (2024) 31 pp. 82-91 [ DOI: doi:10.1038/s41594-023-01143-z Pubmed: 38177670 ]
- Burkholderia needle (chimeric with an anthrax toxin lethal factor tag) (Complex from Bacillus anthracis)
- Human naip and nlrc4 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Lethal factor,type iii secretion system protein (42 kDa, Protein from Burkholderia)
- Zinc ion (65 Da, Ligand)
- The complex of needle, human naip and nlrc4 (Complex)
- Nlr family card domain-containing protein 4 (116 kDa, Protein from Homo sapiens)
- Baculoviral iap repeat-containing protein 1 (160 kDa, Protein from Homo sapiens)
Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8fw2
Q-score: 0.331
Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8fw9
Q-score: 0.24
Structure of NLRC4 CARD filament
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 6k8j
Q-score: 0.05
Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B
Nat Commun (2021) 12 pp. 188-188 [ Pubmed: 33420028 DOI: doi:10.1038/s41467-020-20319-5 ]
- Nlr family card domain-containing protein 4 (11 kDa, Protein from Homo sapiens)
- Nlrc4 card filament (Complex from Homo sapiens)
Cryo-EM structure of NLRC4-CARD filament
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 6mks
Q-score: 0.463
Matyszewski M, Zheng W, Lueck J, Antiochos B, Egelman EH, Sohn J
J Biol Chem (2018) 293 pp. 20240-20248 [ DOI: doi:10.1074/jbc.RA118.006050 Pubmed: 30385506 ]
Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 6b5b
Q-score: 0.188
Tenthorey JL, Haloupek N, Lopez-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacon P, Nogales E, Vance RE
Science (2017) 358 pp. 888-893 [ Pubmed: 29146805 DOI: doi:10.1126/science.aao1140 ]
- Nlrc4 (Complex from Mus musculus)
- Flagellin (58 kDa, Protein from Legionella pneumophila)
- Nlr family card domain-containing protein 4 (116 kDa, Protein from Mus musculus)
- Naip5-nlrc4-flagellin inflammasome (Complex)
- Baculoviral iap repeat-containing protein 1e (159 kDa, Protein from Mus musculus)
- Naip5 (Complex from Mus musculus)
- Flagellin (Complex from Legionella pneumophila)
Cryo electron tomography of Naip5/Nlrc4 inflammasome
Resolution: 40.0 Å
EM Method: Subtomogram averaging
Fitted PDBs: 5aj2
Q-score: 0.039
Diebolder CA, Halff EF, Koster AJ, Huizinga EG, Koning RI
Structure (2015) 23 pp. 2349-2357 [ DOI: doi:10.1016/J.STR.2015.10.001 Pubmed: 26585513 ]
Electron cryo-microscopy of PrgJ/NAIP2/full-length NLRC4 inflammasome with pseudo c12 symmetry
Hu ZH, Zhou Q, Zhang CL, Fan SL, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai JJ
Science (2015) 350 pp. 399-404 [ DOI: doi:10.1126/science.aac5489 Pubmed: 26449475 ]
- Nlrc4 (100 kDa, Protein from Mus musculus)
- Prgj/naip2/full-length nlrc4 inflammasome (1 MDa, Sample)
- Naip2 (Protein from Mus musculus)
- Prgj (Protein from Salmonella enterica subsp. enterica serovar Typhimurium)
Electron cryo-microscopy of PrgJ/NAIP2/full-length NLRC4 inflammasome with pseudo c11 symmetry
Hu ZH, Zhou Q, Zhang CL, Fan SL, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai JJ
Science (2015) 350 pp. 399-404 [ DOI: doi:10.1126/science.aac5489 Pubmed: 26449475 ]
- Nlrc4 (100 kDa, Protein from Mus musculus)
- Naip2 (Protein from Mus musculus)
- Prgj (Protein from Salmonella enterica subsp. enterica serovar Typhimurium)
- Prgj/naip2/full-length nlrc4 inflammasome (1 MDa, Sample)
Electron cryo-microscopy of PrgJ/NAIP2/CARD-truncated NLRC4 inflammasome with pseudo c11 symmetry
Hu ZH, Zhou Q, Zhang CL, Fan SL, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai JJ
Science (2015) 350 pp. 399-404 [ DOI: doi:10.1126/science.aac5489 Pubmed: 26449475 ]
- Nlrc4 (100 kDa, Protein from Mus musculus)
- Prgj/naip2/card-truncated nlrc4 inflammasome (1 MDa, Sample)
- Naip2 (Protein from Mus musculus)
- Prgj (Protein from Salmonella enterica subsp. enterica serovar Typhimurium)