H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8s0c
Q-score: 0.289
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Dna (26-mer) (8 kDa, DNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- H. sapiens orc1-5 (Complex from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- H. sapiens orc1-5 bound to double stranded dna as part of the mcm-orc complex (400 kDa, Complex)
- Dna (26-mer) (7 kDa, DNA from synthetic construct)
- Double stranded dna (Complex from synthetic construct)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
H. sapiens MCM bound to double stranded DNA and ORC1-6
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8s0d
Q-score: 0.346
Weissmann F, Greiwe JF, Puhringer T, Eastwood EL, Couves EC, Miller TCR, Diffley JFX, Costa A
Nature (2024) 636 pp. 499-508 [ Pubmed: 39604733 DOI: doi:10.1038/s41586-024-08263-6 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- H. sapiens mcm (Complex from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna (58-mer) (17 kDa, DNA from synthetic construct)
- H. sapiens orc6 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (101 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna (58-mer) (17 kDa, DNA from synthetic construct)
- Origin recognition complex subunit 6 (28 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- H. sapiens orc1-5 (Complex from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (97 kDa, Protein from Homo sapiens)
- Double stranded dna (Complex from synthetic construct)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- H. sapiens mcm bound to double stranded dna and orc1-6 (1 MDa, Complex)
Cryo-EM structure of an MCM loading intermediate
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6rqc
Q-score: 0.272
Miller TCR, Locke J, Greiwe JF, Diffley JFX, Costa A
Nature (2019) 575 pp. 704-710 [ Pubmed: 31748745 DOI: doi:10.1038/s41586-019-1768-0 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae S288c)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae S288c)
- The mcm-orc (mo) loading intermediate protein complex (Complex from Saccharomyces cerevisiae S288C)
- Dna (88-mer) (27 kDa, DNA from Saccharomyces cerevisiae S288c)
- The mcm-orc (mo) loading intermediate (Complex)
- Dna (88-mer) (27 kDa, DNA from Saccharomyces cerevisiae S288c)
- Origin recognition complex subunit 1 (108 kDa, Protein from Saccharomyces cerevisiae S288c)
- Magnesium ion (24 Da, Ligand)
- Dna (Complex from Saccharomyces cerevisiae S288C)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae S288c)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae S288c)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae S288c)
- Orc1-5-orc6c lobe of the mcm-orc (mo) origin licensing intermediate (Complex)
- Mcm-orc6n lobe of the mcm-orc (mo) origin licensing intermediate. (Complex)
- Zinc ion (65 Da, Ligand)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae S288c)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae S288c)
- Dna replication licensing factor mcm3 (111 kDa, Protein from Saccharomyces cerevisiae S288c)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae S288c)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae S288c)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae S288c)