Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8sl1
Q-score: 0.466
Sridar J, Mafi A, Judge RA, Xu J, Kong KA, Wang JCK, Stoll VS, Koukos G, Simon RJ, Eaton D, Bratkowski M, Hao Q
Commun Chem (2023) 6 pp. 234-234 [ Pubmed: 37898658 DOI: doi:10.1038/s42004-023-01032-y ]
- Zinc ion (65 Da, Ligand)
- Pappalysin-2 (174 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Papp-a2 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Structure of 1:1 PAPP-A.ProMBP complex(half map)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7y5n
Q-score: 0.476
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pappalysin-1 (172 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Structure of 1:1 papp-a/prombp complex(half map) (Complex from Homo sapiens)
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
Structure of 1:1 PAPP-A.STC2 complex(half map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y5q
Q-score: 0.438
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Structure of 1:1 papp-a/stc2 complex(half map) (Complex from Homo sapiens)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)
Structure of 2:2 PAPP-A.ProMBP comple
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8hgg
Q-score: 0.408
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Structure of 2:2 papp-a/prombp complex (Complex from Homo sapiens)
- Pappalysin-1 (181 kDa, Protein from Homo sapiens)
Structure of 2:2 PAPP-A.STC2 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8hgh
Q-score: 0.295
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Structure of 2:2 papp-a/stc2 complex (Complex from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)
PAPP-A dimer in complex with a dimer of the inhibitor STC2
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Papp-a (Protein from Homo sapiens)
- Papp-a (Complex from Homo sapiens)
- Stc2 (Protein from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (400 kDa, Complex)
- Stanniocalcin-2 (Complex from Homo sapiens)
PAPP-A dimer in complex with endogenous STC2 inhibitor.
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Papp-a (Protein from Homo sapiens)
- Stanniocalcin 2 (Protein from Homo sapiens)
- Pregnancy-associated plasma protein a (Complex from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (100 kDa, Complex)
- Stanniocalcin-2 (Complex from Homo sapiens)
Partial dimer complex of PAPP-A and its inhibitor STC2
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8a7d
Q-score: 0.457
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C-terminal part of papp-a (Complex from Homo sapiens)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Papp-a (Complex from Homo sapiens)
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- Partial papp-a dimer in complex with subunit of its endogenous inhibitor stc2 dimer (500 kDa, Complex from Homo sapiens)
- N-terminal part of papp-a (Complex from Homo sapiens)
- Subunit of stanniocalcin-2 (Complex from Homo sapiens)
PAPP-A dimer in complex with its inhibitor STC2 (CASP target)
Resolution: 5.02 Å
EM Method: Single-particle
Fitted PDBs: 8a7e
Q-score: 0.147
Kobbero SD, Gajhede M, Mirza OA, Kloverpris S, Kjaer TR, Mikkelsen JH, Boesen T, Oxvig C
Nat Commun (2022) 13 pp. 6084-6084 [ DOI: doi:10.1038/s41467-022-33698-8 Pubmed: 36257932 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Pappalysin-1 (171 kDa, Protein from Homo sapiens)
- Pregnancy-associated plasma protein a (Complex from Homo sapiens)
- Stanniocalcin-2 (18 kDa, Protein from Homo sapiens)
- Papp-a dimer in complex with its endogenous inhibitor stc2 dimer (100 kDa, Complex from Homo sapiens)
- Stanniocalcin-2 (Complex from Homo sapiens)
Structure of a metalloprotease in complex with its substrate.
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7ufg
Q-score: 0.443
Judge RA, Sridar J, Tunyasunvunakool K, Jain R, Wang JCK, Ouch C, Xu J, Mafi A, Nile AH, Remarcik C, Smith CL, Ghosh C, Xu C, Stoll V, Jumper J, Singh AH, Eaton D, Hao Q
Nat Commun (2022) 13 pp. 5500- [ Pubmed: 36127359 DOI: doi:10.1038/s41467-022-33175-2 ]
- Complex of papp-a with igfbp5 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Insulin-like growth factor-binding protein 5 (30 kDa, Protein from Homo sapiens)
- Pappalysin-1 (176 kDa, Protein from Homo sapiens)