Structure of LAT1-CD98hc in complex with melphalan, focused on TMD
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8kdo
Q-score: 0.417
To Be Published
- Lat1-cd98hc-fab170 (173 kDa, Complex from Homo sapiens)
- (2~{s})-2-azanyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid (305 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
CryoEM structure of a 2,3-hydroxycinnamic acid 1,2-dioxygenase MhpB in substrate bound form
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 9kti
Q-score: 0.603
Dong X, Xu M, Wu M, Wang Y, Cheng X, Jiang W, Zheng D, Omar AH, Cheng Y, Li A, Ma L, Xing Q
J Hazard Mater (2025) 488 pp. 137431-137431 [ Pubmed: 39892151 DOI: doi:10.1016/j.jhazmat.2025.137431 ]
- The decamer complex of mhpb bound with its substrate (Complex from Escherichia coli K-12)
- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (34 kDa, Protein from Escherichia coli K-12)
- Fe (ii) ion (55 Da, Ligand)
- 3-[2,3-bis(oxidanyl)phenyl]propanoic acid (182 Da, Ligand)
A locked conformation of spike protein trimer of Sarbecovirus YN2013
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8zy4
Q-score: 0.568
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (137 kDa, Protein from BtRs-BetaCoV/YN2013)
- The spike protein of yn2013 strain (450 kDa, Cellular component from BtRs-BetaCoV/YN2013)
- 3-[5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoic acid (584 Da, Ligand)
Structure of chanoclavine synthase from Claviceps fusiformis in complex with prechanoclavine
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 9jdc
Q-score: 0.693
Liu ZW, Wang T, Li X, Shen PP, Huang J-W, Chen C-C, Guo R-T
To Be Published
- (2~{s})-2-(methylamino)-3-[4-[(1~{e})-3-methylbuta-1,3-dienyl]-1~{h}-indol-3-yl]propanoic acid (284 Da, Ligand)
- Ergot alkaloid synthesis protein c (Complex from Claviceps fusiformis)
- Catalase easc (54 kDa, Protein from Claviceps fusiformis)
- Protoporphyrin ix containing fe (616 Da, Ligand)
Resolution: 2.37 Å
EM Method: Single-particle
Fitted PDBs: 8yak
Q-score: 0.652
Hu Y, Dai L, Xu Y, Niu D, Yang X, Xie Z, Shen P, Li X, Li H, Zhang L, Min J, Guo RT, Chen CC
Int J Biol Macromol (2024) 278 pp. 134831-134831 [ DOI: doi:10.1016/j.ijbiomac.2024.134831 Pubmed: 39163957 ]
- (2~{s})-2-[[(3~{r})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid (403 Da, Ligand)
- Imidazolonepropionase (43 kDa, Protein from Pseudoxanthomonas wuyuanensis)
- Zinc ion (65 Da, Ligand)
- Pwadh-g88d-d344n (Complex from Pseudoxanthomonas wuyuanensis)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9ivm
Q-score: 0.455
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex in the presence of lsn3318839 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- (2~{r})-2-[2-[1-[(1~{r})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid (480 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Pfr conformer of Arabidopsis thaliana phytochrome B in complex with phytochrome-interacting factor 6
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8yb4
Q-score: 0.522
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ Pubmed: 39317197 DOI: doi:10.1016/j.cell.2024.09.005 ]
- Ternary complex of atphyb-pfr homodimer with atpif6 (120 kDa, Complex from Arabidopsis thaliana)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Pif6 monomer (Complex)
- Phytochrome b (129 kDa, Protein from Arabidopsis thaliana)
- Complex of atphyb-pfr homodimer (Complex from Arabidopsis thaliana)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9iuz
Q-score: 0.473
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ Pubmed: 39317197 DOI: doi:10.1016/j.cell.2024.09.005 ]
- Ternary complex of phyb mutant(y276h) with pif6 (100 kDa, Complex from Arabidopsis thaliana)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Phytochrome b (99 kDa, Protein from Arabidopsis thaliana)
- Pif6 monomer (Complex)
- Complex of phyb mutant(y276h) homodimer (Complex from Arabidopsis thaliana)
Cryo-EM structure of the full-length Pseudomonas aeruginosa bacteriophytochrome in its Pr state
Bodizs S, Meszaros P, Grunewald L, Takala H, Westenhoff S
Structure (2024) 32 pp. 1952-1962.e3 [ Pubmed: 39216473 DOI: doi:10.1016/j.str.2024.08.008 ]
- Homodimeric complex of the protein bacteriophytochrome containing its cofactor biliverdin (160 kDa, Complex from Pseudomonas aeruginosa)
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Bacteriophytochrome (82 kDa, Protein from Pseudomonas aeruginosa)
Cryo-EM structure of the full-length Pseudomonas aeruginosa bacteriophytochrome in its Pfr state
Bodizs S, Meszaros P, Grunewald L, Takala H, Westenhoff S
Structure (2024) 32 pp. 1952-1962.e3 [ Pubmed: 39216473 DOI: doi:10.1016/j.str.2024.08.008 ]
- Homodimeric complex of the protein bacteriophytochrome containing its cofactor biliverdin (160 kDa, Complex from Pseudomonas aeruginosa)
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Bacteriophytochrome (82 kDa, Protein from Pseudomonas aeruginosa)