Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9ivm
Q-score: 0.455
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ DOI: doi:10.1016/j.apsb.2024.09.002 Pubmed: 39664415 ]
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex in the presence of lsn3318839 (Complex from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- (2~{r})-2-[2-[1-[(1~{r})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid (480 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Pfr conformer of Arabidopsis thaliana phytochrome B in complex with phytochrome-interacting factor 6
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8yb4
Q-score: 0.522
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ DOI: doi:10.1016/j.cell.2024.09.005 Pubmed: 39317197 ]
- Complex of atphyb-pfr homodimer (Complex from Arabidopsis thaliana)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Pif6 monomer (Complex)
- Ternary complex of atphyb-pfr homodimer with atpif6 (120 kDa, Complex from Arabidopsis thaliana)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
- Phytochrome b (129 kDa, Protein from Arabidopsis thaliana)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9iuz
Q-score: 0.473
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ DOI: doi:10.1016/j.cell.2024.09.005 Pubmed: 39317197 ]
- Phytochrome b (99 kDa, Protein from Arabidopsis thaliana)
- Complex of phyb mutant(y276h) homodimer (Complex from Arabidopsis thaliana)
- Ternary complex of phyb mutant(y276h) with pif6 (100 kDa, Complex from Arabidopsis thaliana)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Pif6 monomer (Complex)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PS
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8oxa
Q-score: 0.546
Dieudonne T, Kummerer F, Laursen MJ, Stock C, Flygaard RK, Khalid S, Lenoir G, Lyons JA, Lindorff-Larsen K, Nissen P
Nat Commun (2023) 14 pp. 7492-7492 [ DOI: doi:10.1038/s41467-023-42828-9 Pubmed: 37980352 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oxido(dioxo)vanadium (98 Da, Ligand)
- Cell cycle control protein 50a (41 kDa, Protein from Homo sapiens)
- (2~{s})-2-azanyl-3-[[(2~{r})-3-hexadecanoyloxy-2-[(~{z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid (762 Da, Ligand)
- Atp8b1-cdc50a complex (185 kDa, Complex from Homo sapiens)
- Phospholipid-transporting atpase ic (136 kDa, Protein from Homo sapiens)