Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex in the presence of LSN3318839
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9ivm
Q-score: 0.455
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ Pubmed: 39664415 DOI: doi:10.1016/j.apsb.2024.09.002 ]
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex in the presence of lsn3318839 (Complex from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- (2~{r})-2-[2-[1-[(1~{r})-1-[2,6-bis(chloranyl)-3-cyclopropyl-phenyl]ethyl]imidazo[4,5-c]pyridin-6-yl]phenyl]propanoic acid (480 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Pfr conformer of Arabidopsis thaliana phytochrome B in complex with phytochrome-interacting factor 6
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8yb4
Q-score: 0.522
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ Pubmed: 39317197 DOI: doi:10.1016/j.cell.2024.09.005 ]
- Complex of atphyb-pfr homodimer (Complex from Arabidopsis thaliana)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
- Pif6 monomer (Complex)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Phytochrome b (129 kDa, Protein from Arabidopsis thaliana)
- Ternary complex of atphyb-pfr homodimer with atpif6 (120 kDa, Complex from Arabidopsis thaliana)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9iuz
Q-score: 0.473
Wang Z, Wang W, Zhao D, Song Y, Lin X, Shen M, Chi C, Xu B, Zhao J, Deng XW, Wang J
Cell (2024) 187 pp. 6235-6250.e19 [ Pubmed: 39317197 DOI: doi:10.1016/j.cell.2024.09.005 ]
- Complex of phyb mutant(y276h) homodimer (Complex from Arabidopsis thaliana)
- 3-[5-[[(3~{r},4~{r})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{h}-pyrrol-2-yl]methyl]-4-methyl-1~{h}-pyrrol-3-yl]propanoic acid (586 Da, Ligand)
- Phytochrome-interacting factor 6 (11 kDa, Protein from Arabidopsis thaliana)
- Pif6 monomer (Complex)
- Ternary complex of phyb mutant(y276h) with pif6 (100 kDa, Complex from Arabidopsis thaliana)
- Phytochrome b (99 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of PsBphP in Pfr state, Dimer of Dimers FL
Burgie ES, Basore K, Rau MJ, Summers B, Mickles AJ, Grigura V, Fitzpatrick JAJ, Vierstra RD
Nat Commun (2024) 15 pp. 6853-6853 [ DOI: doi:10.1038/s41467-024-50412-y Pubmed: 39127720 ]
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Psbphp (Complex from Pseudomonas syringae pv. tomato str. DC3000)
- Histidine kinase (82 kDa, Protein from Pseudomonas syringae pv. tomato str. DC3000)
Cryo-EM structure of PsBphP in Pfr state, Dimer of Dimers PSM only
Burgie ES, Basore K, Rau MJ, Summers B, Mickles AJ, Grigura V, Fitzpatrick JAJ, Vierstra RD
Nat Commun (2024) 15 pp. 6853-6853 [ DOI: doi:10.1038/s41467-024-50412-y Pubmed: 39127720 ]
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Psbphp (Complex from Pseudomonas syringae pv. tomato str. DC3000)
- Histidine kinase (82 kDa, Protein from Pseudomonas syringae pv. tomato str. DC3000)
Cryo-EM structure of PsBphP in Pfr state, medial PSM only
Burgie ES, Basore K, Rau MJ, Summers B, Mickles AJ, Grigura V, Fitzpatrick JAJ, Vierstra RD
Nat Commun (2024) 15 pp. 6853-6853 [ DOI: doi:10.1038/s41467-024-50412-y Pubmed: 39127720 ]
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Psbphp (Complex from Pseudomonas syringae pv. tomato str. DC3000)
- Histidine kinase (82 kDa, Protein from Pseudomonas syringae pv. tomato str. DC3000)
Cryo-EM structure of PsBphP in Pfr state, splayed PSM only
Burgie ES, Basore K, Rau MJ, Summers B, Mickles AJ, Grigura V, Fitzpatrick JAJ, Vierstra RD
Nat Commun (2024) 15 pp. 6853-6853 [ DOI: doi:10.1038/s41467-024-50412-y Pubmed: 39127720 ]
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Psbphp (Complex from Pseudomonas syringae pv. tomato str. DC3000)
- Histidine kinase (82 kDa, Protein from Pseudomonas syringae pv. tomato str. DC3000)
Cryo-EM structure of PsBphP in Pr state, extended DHp
Burgie ES, Basore K, Rau MJ, Summers B, Mickles AJ, Grigura V, Fitzpatrick JAJ, Vierstra RD
Nat Commun (2024) 15 pp. 6853-6853 [ DOI: doi:10.1038/s41467-024-50412-y Pubmed: 39127720 ]
- 3-[2-[(z)-[3-(2-carboxyethyl)-5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(z)-[(3e)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-3- yl]propanoic acid (585 Da, Ligand)
- Psbphp (Complex from Pseudomonas syringae pv. tomato str. DC3000)
- Histidine kinase (82 kDa, Protein from Pseudomonas syringae pv. tomato str. DC3000)
LPS-bound P2Y10 in complex with G13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kgg
Q-score: 0.518
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y
Cell Chem Biol (2024) 31 pp. 1899-1908.e5 [ Pubmed: 39265572 DOI: doi:10.1016/j.chembiol.2024.08.005 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Putative p2y purinoceptor 10 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the Naproxen-bound state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8jh5
Q-score: 0.44
To Be Published
- Auxin efflux carrier component 1 (67 kDa, Protein from Arabidopsis thaliana)
- Binary complex of pin1 with nanobody (Complex from Arabidopsis thaliana)
- Nanobody (13 kDa, Protein from Escherichia coli)
- (2s)-2-(6-methoxynaphthalen-2-yl)propanoic acid (230 Da, Ligand)