Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cgp
Q-score: 0.408
Iyer KA, Kobayashi T, Murayama T, Samso M
Structure (2024) [ Pubmed: 39708816 DOI: doi:10.1016/j.str.2024.11.018 ]
- Zinc ion (65 Da, Ligand)
- Dantrolene (314 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1 disease mutant y523s with fkbp12.6, nanodisc and inhibitor dantrolene in the absence of calcium with refined p1 domain (2 MDa, Complex from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9cgq
Q-score: 0.463
Iyer KA, Kobayashi T, Murayama T, Samso M
To Be Published
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1 disease mutant y523s with fkbp12.6, nanodisc and inhibitor dantrolene in the presence of activating calcium with refined p1 domain (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dantrolene (314 Da, Ligand)
Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Flubendiamide (682 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Tetraniliprole (544 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlf
Q-score: 0.375
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Chimeric ryr ca2+/atp/caffeine/cam1234 (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlh
Q-score: 0.386
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Chimeric ryr-c4657m/g4819e ca2+/atp/caffeine/cam1234 (2 MDa, Complex from Oryctolagus cuniculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8y40
Q-score: 0.306
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Chimeric ryr-i4657m/g4819e ca2+/atp/caffeine/cam1234/chl (2 MDa, Complex from Oryctolagus cuniculus)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
Composite map of mink RyR3 in closed conformation
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 9c1e
Q-score: 0.575
Chen YS, Garcia-Castaneda M, Charalambous M, Rossi D, Sorrentino V, Van Petegem F
Nat Commun (2024) 15 pp. 8630-8630 [ Pubmed: 39366997 DOI: doi:10.1038/s41467-024-52998-9 ]
- Chloride ion (35 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 3 (551 kDa, Protein from Neogale vison)
- Zinc ion (65 Da, Ligand)
- Mink ryr3 + fkbp12.6 (2 MDa, Complex from Neogale vison)
Composite map of mink RyR3 in open conformation bound to Ca2+/ATP/caffeine
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 9c1f
Q-score: 0.553
Chen YS, Garcia-Castaneda M, Charalambous M, Rossi D, Sorrentino V, Van Petegem F
Nat Commun (2024) 15 pp. 8630-8630 [ Pubmed: 39366997 DOI: doi:10.1038/s41467-024-52998-9 ]
- Chloride ion (35 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Caffeine (194 Da, Ligand)
- Ryanodine receptor 3 (551 kDa, Protein from Neogale vison)
- Zinc ion (65 Da, Ligand)
- Mink ryr3 + fkbp12.6 (2 MDa, Complex from Neogale vison)